Document Detail


Vascular endothelial cells and dysfunctions: role of melatonin.
MedLine Citation:
PMID:  23276975     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Several pathological conditions, including hypertension, atherosclerosis, diabetes, ischemia/reperfusion injury and nicotine-induced vasculopathy, are associated with vascular endothelial dysfunction characterized by altered secretory output of endothelial cells. Therefore there is a search for molecules and interventions that could restore endothelial function, in particular augmenting NO production, reducing the generation of free radicals and vasoconstrictors and preventing undesired inflammation. The pineal hormone melatonin exhibits several endothelium protective properties: it scavenges free radicals, activates antioxidant defence enzymes, normalizes lipid and blood pressure profile and increases NO bioavailability. Melatonin improved vascular function in experimental hypertension, reducing intimal infiltration and restoring NO production. Melatonin improved the NO pathway also in animal models for the study of diabetes and prevented NO down-regulation and adhesive molecules up-regulation in nicotine-induced vasculopathy. The protection against endothelial damage, vasoconstriction, platelet aggregation and leukocyte infiltration might contribute to the beneficial effects against ischemia-reperfusion injury by melatonin. Therefore, melatonin administration has endothelium-protective potential in several pathological conditions. Nevertheless, it still needs to be established, whether melatonin is able to revert already established endothelial dysfunction in these conditions.
Authors:
Luigi Fabrizio Rodella; Gaia Favero; Eleonora Foglio; Claudia Rossini; Stefania Castrezzati; Claudio Lonati; Rita Rezzani
Related Documents :
10497845 - Angiogenesis: state of the art.
12828735 - A tissue-engineered endothelialized dermis to study the modulation of angiogenic and an...
20733505 - Scvegf microbubble ultrasound contrast agents: a novel probe for ultrasound molecular i...
10974345 - Sdf-1 activity on microvascular endothelial cells: consequences on angiogenesis in in v...
11058875 - Expression and regulation of neuropilin-1 in human astrocytomas.
15947785 - Impairing the bioenergetic status and the biogenesis of mitochondria triggers mitophagy...
Publication Detail:
Type:  Journal Article     Date:  2013-01-01
Journal Detail:
Title:  Frontiers in bioscience (Elite edition)     Volume:  5     ISSN:  1945-0508     ISO Abbreviation:  Front Biosci (Elite Ed)     Publication Date:  2013  
Date Detail:
Created Date:  2013-01-01     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101485240     Medline TA:  Front Biosci (Elite Ed)     Country:  United States    
Other Details:
Languages:  eng     Pagination:  119-29     Citation Subset:  IM    
Affiliation:
Section of Human Anatomy, Department of Biomedical Sciences and Biotechnologies, Viale Europa 11, 25124 Brescia, Italy.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Obesity-associated endometrial and cervical cancers.
Next Document:  Hematopoietic modulators as potential agents for the treatment of leukemia.