| Vascular elasticity of systemic lupus erythematosus patients is associated with steroids and hydroxychloroquine treatment. | |
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MedLine Citation:
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PMID: 17893967 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We studied the large and small artery elasticity (AE) and systemic vascular resistance (SVR) of systemic lupus erythematosus (SLE) patients according to treatment profile. Forty-one SLE patients (90% female, mean age 48.7 +/- 2.4 years) were compared to 96 healthy controls. The large and small AE and the SVR were derived from radial artery waveforms (model CR-2000, HDI Inc.). Patients were categorized into groups according to treatment: steroid (12), hydroxychloroquine (HCQ) (9), steroid+HCQ (16), and no-steroids-no-HCQ (4). The steroid group had reduced large AE and increased SVR as compared to the HCQ group (8.3 mmHg x mL x 10 and 18.4 dyne x sec x 10(-3) versus 13.7 and 14.4, respectively). Mean large AE and the SVR of the HCQ group was similar to that of the controls (11.8 mmHg x mL x 10 and 14.5 dyne x sec x 10(-3), respectively). Mean large AE and SVR of the steroid+HCQ group were better than the steroid group (10.4 mmHg x mL x 10 and 16.0 dyne x sec x 10(-3)). Patients that received steroids had higher rates of hypertension (36%) and diabetes (1%) compared to rest of the patients (15% and 0%, respectively). Small AE, blood pressure, CRP, and SLEDAI were similar between the groups. Among SLE patients, steroid treatment was associated with the highest degree of vascular damage, and HCQ was associated with the lowest degree of vascular damage. It is possible that the steroids are responsible in part to the increased large-vessel manifestations observed in these patients, and that HCQ might have a protective effect on the vessel wall. |
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Authors:
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Amir Tanay; Eyal Leibovitz; Angela Frayman; Reuven Zimlichman; Marina Shargorodsky; Dov Gavish |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Annals of the New York Academy of Sciences Volume: 1108 ISSN: 0077-8923 ISO Abbreviation: Ann. N. Y. Acad. Sci. Publication Date: 2007 Jun |
Date Detail:
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Created Date: 2007-09-25 Completed Date: 2007-10-30 Revised Date: 2007-12-10 |
Medline Journal Info:
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Nlm Unique ID: 7506858 Medline TA: Ann N Y Acad Sci Country: United States |
Other Details:
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Languages: eng Pagination: 24-34 Citation Subset: IM |
Affiliation:
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Rheumatology Unit, Wolfson Medical Center, Holon, Israel. tanai@post.tau.ac.il |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adrenal Cortex Hormones
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adverse effects* Antirheumatic Agents / therapeutic use* Arteries / drug effects Diabetes Mellitus Elasticity / drug effects Female Humans Hydroxychloroquine / therapeutic use* Hypertension / complications Lupus Erythematosus, Systemic / complications, drug therapy* Male Middle Aged Muscle, Smooth, Vascular / drug effects* Vascular Resistance / drug effects |
| Chemical | |
Reg. No./Substance:
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0/Adrenal Cortex Hormones; 0/Antirheumatic Agents; 118-42-3/Hydroxychloroquine |
| Comments/Corrections | |
Erratum In:
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Ann N Y Acad Sci. 2007;1114:464 Note: Shargorodsky, Marina [added] |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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