Document Detail

Vascular effects of piretanide. Studies on extrarenal action in several animal models.
MedLine Citation:
PMID:  6685507     Owner:  NLM     Status:  MEDLINE    
4-Phenoxy-3-(1-pyrrolidinyl)-5-sulfamoyl benzoic acid (piretanide, Arelix) was studied for its vasoactive effects in several experimental models. In rat and rabbit thoracic aorta strips, piretanide dose-dependently attenuated contractions induced by norepinephrine (noradrenaline). When contractions were induced by KCl no concentration response curve could be established. Piretanide inhibited the vasoconstrictor response to norepinephrine and to KCl in the rat mesenteric vascular bed. IC50's of 0.5 mmol/l and 4.9 mmol/l, resp., were calculated. In bovine coronary artery strips piretanide caused a marked relaxation. The vasoconstrictor response to PGE2 in piretanide superfused preparations was attenuated in a concentration related manner. Infusion of piretanide (1 mg X ml-1 X min-1) in the isolated guinea pig heart produced a reversible increase of coronary flow. In both normotensive and spontaneously hypertensive bilaterally nephrectomized pithed rats piretanide caused a significant reduction of diastolic blood pressure. The results contribute to the understanding of the antihypertensive effect of piretanide.
E Klaus; H G Alpermann; G Caspritz; W Linz; B Schölkens
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Publication Detail:
Type:  Comparative Study; In Vitro; Journal Article    
Journal Detail:
Title:  Arzneimittel-Forschung     Volume:  33     ISSN:  0004-4172     ISO Abbreviation:  Arzneimittelforschung     Publication Date:  1983  
Date Detail:
Created Date:  1983-12-20     Completed Date:  1983-12-20     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0372660     Medline TA:  Arzneimittelforschung     Country:  GERMANY, WEST    
Other Details:
Languages:  eng     Pagination:  1273-6     Citation Subset:  IM    
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MeSH Terms
Aorta, Thoracic / drug effects
Blood Pressure / drug effects
Coronary Circulation / drug effects
Coronary Vessels / drug effects
Diuretics / pharmacology*
Guinea Pigs
Hemodynamics / drug effects*
Rats, Inbred Strains
Species Specificity
Splanchnic Circulation / drug effects
Sulfonamides / pharmacology*
Reg. No./Substance:
0/Diuretics; 0/Sulfonamides; 55837-27-9/piretanide

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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