Document Detail

Vascular effects of the peptides PYY and PHI: comparison with APP and VIP.
MedLine Citation:
PMID:  6897040     Owner:  NLM     Status:  MEDLINE    
Local infusions of PYY (3-100 pmol.min-1) caused a slowly developing vasoconstriction of a long duration in the cat submandibular salivary gland. The vasoconstrictor action of PYY was also present after alpha-adrenoceptor blockade and in sympathectomized animals. Local APP infusions caused only weak vasoconstriction. Infusions of PHI and synthetic PHI caused an atropine-resistant submandibular vasodilation. On a molar basis PHI was, however, almost 1000-fold less potent than VIP as vasodilating agent.
J M Lundberg; K Tatemoto
Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  European journal of pharmacology     Volume:  83     ISSN:  0014-2999     ISO Abbreviation:  Eur. J. Pharmacol.     Publication Date:  1982 Sep 
Date Detail:
Created Date:  1982-12-21     Completed Date:  1982-12-21     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  1254354     Medline TA:  Eur J Pharmacol     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  143-6     Citation Subset:  IM    
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MeSH Terms
Atropine / pharmacology
Gastrointestinal Hormones / pharmacology*
Hemodynamics / drug effects*
Injections, Intra-Arterial
Pancreatic Polypeptide / pharmacology*
Peptide PHI
Peptide YY
Peptides / pharmacology*
Regional Blood Flow / drug effects
Submandibular Gland / blood supply
Vasoactive Intestinal Peptide / pharmacology*
Vasodilator Agents
Reg. No./Substance:
0/Gastrointestinal Hormones; 0/Peptide PHI; 0/Peptides; 0/Vasodilator Agents; 106388-42-5/Peptide YY; 37221-79-7/Vasoactive Intestinal Peptide; 51-55-8/Atropine; 58591-52-9/pancreatic polypeptide, avian; 59763-91-6/Pancreatic Polypeptide

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