| Vascular effects of a local anesthetic mixture in atopic dermatitis. | |
| | |
MedLine Citation:
|
PMID: 6208728 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
An anesthetic cream with an eutectic mixture of 5% lidocaine and 5% prilocaine has been tested on the skin of healthy subjects and patients with atopic dermatitis and generalized eczema. In healthy subjects a blanching was seen when the analgesia was complete after 30-60 min. In the dry skin and eczematous lesions of atopic dermatitis an application time of 5-15 min caused a blanching and a good analgesia. When applied for 30-60 min the eczematous skin became increasingly red and in one patient purpura appeared. The white dermographism turned red in treated areas. The abnormal vascular reactions to the cream in diseased skin can be explained by a rapid and increased percutaneous absorption of the anesthetics. A shortened application time is here recommended. |
| | |
Authors:
|
L Juhlin; O Rollman |
Related Documents
:
|
1549378 - Skin endpoint titration. still the standard? 19415578 - Collagen-based dermal fillers: past, present, future. 12055798 - A leishmanin skin test survey in the human population of l'alacantí region (spain): im... 20593018 - First-in-man open clinical trial of a combined rdesat-6 and rcfp-10 tuberculosis specif... 15796098 - Otoacoustic emissions in the general adult population of nord-trøndelag, norway: iii. ... 22631858 - Quantitative detection of pfhrp2 in saliva of malaria patients in the philippines. |
Publication Detail:
|
Type: Clinical Trial; Controlled Clinical Trial; Journal Article |
Journal Detail:
|
Title: Acta dermato-venereologica Volume: 64 ISSN: 0001-5555 ISO Abbreviation: Acta Derm. Venereol. Publication Date: 1984 |
Date Detail:
|
Created Date: 1984-12-18 Completed Date: 1984-12-18 Revised Date: 2004-11-17 |
Medline Journal Info:
|
Nlm Unique ID: 0370310 Medline TA: Acta Derm Venereol Country: SWEDEN |
Other Details:
|
Languages: eng Pagination: 439-40 Citation Subset: IM |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adolescent Adult Aged Anesthetics, Local* Dermatitis, Atopic / physiopathology* Drug Combinations Eczema / physiopathology Humans Lidocaine* Middle Aged Ointments Prilocaine* Skin / blood supply* Time Factors |
| Chemical | |
Reg. No./Substance:
|
0/Anesthetics, Local; 0/Drug Combinations; 0/Ointments; 137-58-6/Lidocaine; 721-50-6/Prilocaine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Effect of grenz rays on Langerhans' cells in human epidermis.
Next Document: Pregnancy and porphyria cutanea tarda.