Document Detail

Vascular effects of a local anesthetic mixture in atopic dermatitis.
MedLine Citation:
PMID:  6208728     Owner:  NLM     Status:  MEDLINE    
An anesthetic cream with an eutectic mixture of 5% lidocaine and 5% prilocaine has been tested on the skin of healthy subjects and patients with atopic dermatitis and generalized eczema. In healthy subjects a blanching was seen when the analgesia was complete after 30-60 min. In the dry skin and eczematous lesions of atopic dermatitis an application time of 5-15 min caused a blanching and a good analgesia. When applied for 30-60 min the eczematous skin became increasingly red and in one patient purpura appeared. The white dermographism turned red in treated areas. The abnormal vascular reactions to the cream in diseased skin can be explained by a rapid and increased percutaneous absorption of the anesthetics. A shortened application time is here recommended.
L Juhlin; O Rollman
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Publication Detail:
Type:  Clinical Trial; Controlled Clinical Trial; Journal Article    
Journal Detail:
Title:  Acta dermato-venereologica     Volume:  64     ISSN:  0001-5555     ISO Abbreviation:  Acta Derm. Venereol.     Publication Date:  1984  
Date Detail:
Created Date:  1984-12-18     Completed Date:  1984-12-18     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0370310     Medline TA:  Acta Derm Venereol     Country:  SWEDEN    
Other Details:
Languages:  eng     Pagination:  439-40     Citation Subset:  IM    
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MeSH Terms
Anesthetics, Local*
Dermatitis, Atopic / physiopathology*
Drug Combinations
Eczema / physiopathology
Middle Aged
Skin / blood supply*
Time Factors
Reg. No./Substance:
0/Anesthetics, Local; 0/Drug Combinations; 0/Ointments; 137-58-6/Lidocaine; 721-50-6/Prilocaine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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