Document Detail


Vascular dynamics of a shape memory polymer foam aneurysm treatment technique.
MedLine Citation:
PMID:  17676399     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The vascular dynamics of a shape memory polymer foam aneurysm treatment technique are assessed through the simulated treatment of a generic basilar aneurysm using coupled fluid dynamics and heat transfer calculations. The shape memory polymer foam, which expands to fill the aneurysm when heated, is modeled at three discrete stages of the treatment procedure. To estimate an upper bound for the maximum amount of thermal damage due to foam heating, a steady velocity is specified through the basilar artery, corresponding to a minimum physiological flow velocity over a cardiac cycle. During expansion, the foam alters the flow patterns within the aneurysm by shielding the aneurysm dome from a confined jet that issues from the basilar artery. The time scales for thermal damage to the artery walls and surrounding blood flow are computed from the temperature field. The flow through the post-treatment bifurcation is comprised of two counter-rotating vortex tubes that are located beneath the aneurysm neck and extend downstream into the outlet arteries. Beneath the aneurysm neck, a marked increase in the wall shear stress is observed due to the close proximity of the counter-rotating vortex tubes to the artery wall.
Authors:
Jason Ortega; Duncan Maitland; Tom Wilson; William Tsai; Omer Savaş; David Saloner
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.     Date:  2007-08-04
Journal Detail:
Title:  Annals of biomedical engineering     Volume:  35     ISSN:  0090-6964     ISO Abbreviation:  Ann Biomed Eng     Publication Date:  2007 Nov 
Date Detail:
Created Date:  2007-10-23     Completed Date:  2008-01-08     Revised Date:  2012-11-16    
Medline Journal Info:
Nlm Unique ID:  0361512     Medline TA:  Ann Biomed Eng     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1870-84     Citation Subset:  IM    
Affiliation:
Engineering, Lawrence Livermore National Laboratory, P.O. Box 808, L-644, Livermore, CA 94551, USA. ortega17@llnl.gov
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MeSH Terms
Descriptor/Qualifier:
Basilar Artery / physiopathology
Blood Flow Velocity
Computer Simulation
Humans
Intracranial Aneurysm / physiopathology,  therapy*
Models, Cardiovascular
Polymers / chemistry*,  therapeutic use*
Stress, Mechanical
Temperature
Grant Support
ID/Acronym/Agency:
R01 EB000462/EB/NIBIB NIH HHS; R01EB000462/EB/NIBIB NIH HHS
Chemical
Reg. No./Substance:
0/Polymers

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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