Document Detail

Vascular distribution in ruptured canine cranial cruciate ligament.
MedLine Citation:
PMID:  21204860     Owner:  NLM     Status:  In-Data-Review    
Objective: To (1) determine the microanatomic vascular distribution in ruptured canine cranial cruciate ligaments (CCL) using specific vascular immunohistochemical techniques, and (2) compare vessel density between ruptured and intact canine CCL and between different areas of interest in ruptured CCL using histomorphometric analysis. Study Design: In vitro study. Animals: Dogs (n=41) admitted for surgical treatment of ruptured CCL and 19 dogs euthanatized for nonorthopedic conditions. Methods: Diseased (variable CCL rupture) and intact (normal control) CCL were processed for immunohistochemical staining specific to vessels (factor VIII, laminin). Mean vascular density was assessed and compared in areas of interest (torn end versus remaining core regions of CCL, proximal femoral versus distal tibial core CCL regions). Results: Ruptured CCL was more vascular than intact CCL; however there was no difference in vascular density between the torn end and the remaining core area of the ruptured CCL. Ruptured CCL was vascularized to a greater degree at the proximal portion than the distal portion of the CCL. Partially ruptured CCLs had a higher vessel density than completely ruptured CCLs. Conclusions: Vascular density is increased in diseased CCL compared with intact CCL. It remains to be determined whether this finding is associated with the cause of CCL rupture or is a result of CCL degeneration and rupture.
Kei Hayashi; Jitender Bhandal; Carlos O Rodriguez; Sun Young Kim; Rachel Entwistle; Diane Naydan; Amy Kapatkin; Susan M Stover
Publication Detail:
Type:  Journal Article     Date:  2011-01-04
Journal Detail:
Title:  Veterinary surgery : VS : the official journal of the American College of Veterinary Surgeons     Volume:  40     ISSN:  1532-950X     ISO Abbreviation:  Vet Surg     Publication Date:  2011 Feb 
Date Detail:
Created Date:  2011-02-03     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8113214     Medline TA:  Vet Surg     Country:  United States    
Other Details:
Languages:  eng     Pagination:  198-203     Citation Subset:  IM    
Copyright Information:
© Copyright 2010 by The American College of Veterinary Surgeons.
JD Wheat Veterinary Orthopedic Research Laboratory, School of Veterinary Medicine, University of California Davis, Davis, CA Department of Surgical and Radiological Sciences, School of Veterinary Medicine, University of California Davis, Davis, CA William R. Pritchard Veterinary Medical Teaching Hospital, School of Veterinary Medicine, University of California Davis, Davis, CA.
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