Document Detail


Vascular development: molecular logic for defining arteries and veins.
MedLine Citation:
PMID:  12579039     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Vascular development is a complex process. In the past decade, significant advances have been made in the understanding of molecular mechanisms underlying vascular system development. Most recently, a model describing a signaling pathway that governs the differentiation of arteries and veins has emerged. Furthermore, the idea that angiogenesis of arteries and veins are coordinately but also differentially regulated has been proposed based on several pieces of molecular evidence. This article discusses the historical background leading to these most recent discoveries of signaling pathways that dictate arterial-venous formation and proposes a model that describes how arterial and venous systems are specified and established. The article also discusses future perspectives of this exciting area of vascular development in concluding remarks.
Authors:
Thomas N Sato
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.; Review    
Journal Detail:
Title:  Current opinion in hematology     Volume:  10     ISSN:  1065-6251     ISO Abbreviation:  Curr. Opin. Hematol.     Publication Date:  2003 Mar 
Date Detail:
Created Date:  2003-02-11     Completed Date:  2003-11-06     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  9430802     Medline TA:  Curr Opin Hematol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  131-5     Citation Subset:  IM    
Affiliation:
University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390-8573, USA. island1005@aol.com
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MeSH Terms
Descriptor/Qualifier:
Animals
Arteries / cytology,  growth & development
Blood Vessels / growth & development*
Growth Substances / physiology
Humans
Neovascularization, Physiologic
Signal Transduction
Veins / cytology,  growth & development
Grant Support
ID/Acronym/Agency:
R01 HL61294/HL/NHLBI NIH HHS; R01 HL63880/HL/NHLBI NIH HHS; R01 HL65187/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
0/Growth Substances

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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