Document Detail


Vascular development in the zebrafish.
MedLine Citation:
PMID:  22553495     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The zebrafish has emerged as an excellent vertebrate model system for studying blood and lymphatic vascular development. The small size, external and rapid development, and optical transparency of zebrafish embryos are some of the advantages the zebrafish model system offers. Multiple well-established techniques have been developed for imaging and functionally manipulating vascular tissues in zebrafish embryos, expanding on and amplifying these basic advantages and accelerating use of this model system for studying vascular development. In the past decade, studies performed using zebrafish as a model system have provided many novel insights into vascular development. In this article we discuss the amenability of this model system for studying blood vessel development and review contributions made by this system to our understanding of vascular development.
Authors:
Aniket V Gore; Kathryn Monzo; Young R Cha; Weijun Pan; Brant M Weinstein
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Intramural; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Cold Spring Harbor perspectives in medicine     Volume:  2     ISSN:  2157-1422     ISO Abbreviation:  Cold Spring Harb Perspect Med     Publication Date:  2012 May 
Date Detail:
Created Date:  2012-05-03     Completed Date:  2013-06-17     Revised Date:  2013-06-25    
Medline Journal Info:
Nlm Unique ID:  101571139     Medline TA:  Cold Spring Harb Perspect Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  a006684     Citation Subset:  IM    
Affiliation:
Program in Genomics of Differentiation, Laboratory of Molecular Genetics, Section on Vertebrate Organogenesis, NICHD, NIH, Bethesda, Maryland, USA.
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MeSH Terms
Descriptor/Qualifier:
Animals
Blood Vessels / embryology*
Brain / blood supply
Capillary Permeability / physiology
Endothelial Cells / physiology
Endothelium, Vascular / embryology
Kidney / blood supply
Lymphatic System / embryology
Microtubules
Neovascularization, Physiologic / physiology*
Receptors, Vascular Endothelial Growth Factor / physiology
Signal Transduction / physiology
Tubulin
Vascular Endothelial Growth Factor A / physiology
Zebrafish / embryology*
Chemical
Reg. No./Substance:
0/Tubulin; 0/Vascular Endothelial Growth Factor A; EC 2.7.10.1/Receptors, Vascular Endothelial Growth Factor
Comments/Corrections

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