Document Detail

Vascular compliance in sodium-sensitive and sodium-resistant borderline hypertensive patients.
MedLine Citation:
PMID:  7731143     Owner:  NLM     Status:  MEDLINE    
Recently, we demonstrated a reduction in the compliance of the carotid, femoral and brachial arteries in sodium-sensitive subjects who had consumed a regular sodium intake of approximately 120 mmol per day, as compared to both sodium-resistant borderline hypertensive subjects and normotensive controls. Venous compliance was not different between the two borderline hypertensive groups and was only slightly lesser than in controls. Large artery compliance was studied using a non-invasive ultrasound vessel wall movement detector system, while venous compliance was determined by means of strain gauge plethysmography. The borderline hypertensive subjects were subsequently treated with enalapril 10 mg/day, felodipine 5 mg/day or placebo during six months. Despite similar reductions in blood pressure, enalapril induced a significant increase of the muscular femoral and brachial artery compliance, but not of the elastic carotid artery, while felodipine did not influence large artery compliance at all in the sodium-sensitive group. The effect of enalapril on muscular artery compliance was established through a dose-dependent increase in distension and not through a change in arterial diameter. Arterial compliance was not influenced by either of the drugs in the resistant group. Venous compliance was also not altered by the medication. In conclusion, femoral and brachial artery compliance in sodium-sensitive borderline hypertensive subjects, which was found to be lower than that of sodium-resistant subjects, improved with antihypertensive treatment with enalapril but not with felodipine, despite the similar reductions in blood pressure induced by both drugs.(ABSTRACT TRUNCATED AT 250 WORDS)
P Draaijer; M J Kool; L M van Bortel; F Nieman; P W de Leeuw; J P van Hooff; K M Leunissen
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Publication Detail:
Type:  Clinical Trial; Controlled Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Kidney international     Volume:  47     ISSN:  0085-2538     ISO Abbreviation:  Kidney Int.     Publication Date:  1995 Jan 
Date Detail:
Created Date:  1995-06-01     Completed Date:  1995-06-01     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0323470     Medline TA:  Kidney Int     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  169-76     Citation Subset:  IM    
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MeSH Terms
Blood Pressure / physiology
Blood Vessels / physiopathology*
Diet, Sodium-Restricted*
Echocardiography, Doppler
Enalapril / therapeutic use
Felodipine / therapeutic use
Hypertension / drug therapy,  physiopathology*
Middle Aged
Renin-Angiotensin System / physiology
Vascular Resistance
Reg. No./Substance:
72509-76-3/Felodipine; 75847-73-3/Enalapril

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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