| Vascular changes in hypertensive patients with different left ventricular geometry. | |
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MedLine Citation:
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PMID: 8903636 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To evaluate vascular structural changes in hypertensive patients with different patterns of left ventricular geometry. DESIGN AND METHODS: From 250 untreated hypertensive patients who underwent ambulatory blood pressure monitoring and echocardiographic study, we selected four groups matched for sex, age, body mass index, smoking habits and serum lipid values: 25 hypertensive subjects with normal left ventricular geometry, 16 with concentric left ventricular remodeling, 26 with concentric left ventricular hypertrophy and 18 with eccentric non-dilated left ventricular hypertrophy. These patients underwent carotid ultrasonography to evaluate the intimal-medial thickness and lumen diameter, and venous occlusion plethysmography to record minimum forearm vascular resistance (an index of arteriolar structural changes). RESULTS: The intimal-medial thickness and minimum forearm vascular resistance were significantly higher (both P<0.05) in hypertensive subjects with concentric left ventricular remodeling (0.95 mm, 2.68 RU) and concentric left ventricular hypertrophy (0.96 mm, 2.71 RU) than in those with eccentric non-dilated left ventricular hypertrophy (0.81 mm, 2.36 RU) and normal left ventricular geometry (0.71 mm, 2.15 RU). There was no difference between hypertensive patients with concentric left ventricular remodeling and concentric left ventricular hypertrophy. The intimal-medial thickness and minimum forearm vascular resistance tended to be higher in hypertensive subjects with eccentric non-dilated left ventricular hypertrophy than in those with normal left ventricular geometry, but this difference did not attain statistical significance. CONCLUSIONS: This study shows that the spectrum of cardiac adaptation to hypertension is associated with a spectrum of vascular adaptation which might be related both to hemodynamic stimuli and differences in the expression or activity of vascular growth factors. |
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Authors:
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S D Pierdomenico; D Lapenna; M D Guglielmi; E Porreca; T Antidormi; F Cuccurullo; A Mezzetti |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of hypertension Volume: 13 ISSN: 0263-6352 ISO Abbreviation: J. Hypertens. Publication Date: 1995 Dec |
Date Detail:
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Created Date: 1997-03-19 Completed Date: 1997-03-19 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 8306882 Medline TA: J Hypertens Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 1701-6 Citation Subset: IM |
Affiliation:
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Hypertension Study and Treatment Center, Institute of Pathophysiology, G. D'Annunzio University, Chieti, Italy. |
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| MeSH Terms | |
Descriptor/Qualifier:
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Blood Flow Velocity Blood Pressure Monitoring, Ambulatory Carotid Arteries / physiopathology, ultrasonography* Echocardiography Female Forearm / blood supply Humans Hypertension / physiopathology*, ultrasonography Hypertrophy, Left Ventricular / physiopathology, ultrasonography* Male Middle Aged Plethysmography Vascular Resistance |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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