Document Detail

Vascular calcifications seen on mammography: an independent factor indicating coronary artery disease.
MedLine Citation:
PMID:  19690660     Owner:  NLM     Status:  MEDLINE    
PURPOSE: Establish a relationship between vascular calcifications seen via mammography and coronary artery disease, estimate the risk ratios, and investigate the interrelationships between vascular calcification and other risk factors for coronary artery disease.
MATERIALS AND METHODS: This was a case-control study consisting of 40 women with coronary artery disease in the case group and 40 women without any history of coronary artery disease in the control group who were matched according to age. The study was approved by the Institution's Research Ethics Committee (consent statement was obtained). Odds ratios and confidence intervals were calculated using univariate analysis. Interrelationships among other risk factors, such as arterial hypertension, dyslipidemia, smoking and diabetes mellitus, were calculated using multivariate analysis. A p <0.05 was considered to be significant for statistical analysis.
RESULTS: The mean ages for the case and control groups were 64.65 years and 63.88 years, respectively. In multivariate analysis, the only variables related to coronary artery disease were Vascular calcification [OR 4.71 (CI 1.36-16.33) p=0.014], family history [OR 5.76 (CI 1.58-21.03) p=0.008] and arterial hypertension [OR 15.92 (CI 3.12-81.14) p=0.001]. Although smoking and diabetes are important variables in the pathogenesis of coronary artery disease, these factors did not show statistically significant associations in this sample.
CONCLUSION: The presence of vascular calcifications seen via mammography was an independent risk factor for coronary artery disease, as were hypertension and a family history of coronary artery disease.
Evelling L C Oliveira; Ruffo Freitas-Junior; Abrahão Afiune-Neto; Eddie F C Murta; Júlio E Ferro; Aline F B Melo
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Clinics (São Paulo, Brazil)     Volume:  64     ISSN:  1980-5322     ISO Abbreviation:  Clinics (Sao Paulo)     Publication Date:  2009  
Date Detail:
Created Date:  2009-08-19     Completed Date:  2010-05-05     Revised Date:  2013-05-31    
Medline Journal Info:
Nlm Unique ID:  101244734     Medline TA:  Clinics (Sao Paulo)     Country:  Brazil    
Other Details:
Languages:  eng     Pagination:  763-7     Citation Subset:  IM    
Department of Gynecology and Obstetrics, School of Medicine of the Federal University of Goiás, Goiânia/GO, Brazil.
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MeSH Terms
Breast Diseases / radiography*
Calcinosis / radiography*
Coronary Artery Disease / etiology*
Epidemiologic Methods
Family Characteristics
Hypertension / complications
Middle Aged
Vascular Diseases / radiography*

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