Document Detail

Vascular calcification and hypertension: cause and effect.
MedLine Citation:
PMID:  22713153     Owner:  NLM     Status:  MEDLINE    
Vascular calcification is an active and regulated process which is integral to cardiovascular disease and intimately linked to hypertension. Dysfunctional vascular smooth muscle cells, microvesicles, and dysregulated mineralization inhibitors play key roles in the calcification process, which occurs in the vessel intima in association with atherosclerosis as well as in the vessel media during ageing. Historically hypertension was considered a risk factor promoting atherosclerosis and associated intimal calcification. However, it is now recognized that not all vascular calcification occurs with atherosclerosis, and calcification of the vessel media is associated with arterial stiffening and is a major cause of isolated systolic hypertension in the elderly. Importantly, vascular calcification, regardless of its anatomical site, is an independent risk factor for cardiovascular mortality. Therefore, understanding the factors and mechanisms driving these processes will provide novel therapeutic targets for its prevention and perhaps ultimately its regression.
Sundeep S Kalra; Catherine M Shanahan
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Annals of medicine     Volume:  44 Suppl 1     ISSN:  1365-2060     ISO Abbreviation:  Ann. Med.     Publication Date:  2012 Jun 
Date Detail:
Created Date:  2012-06-20     Completed Date:  2012-11-28     Revised Date:  2014-02-20    
Medline Journal Info:
Nlm Unique ID:  8906388     Medline TA:  Ann Med     Country:  England    
Other Details:
Languages:  eng     Pagination:  S85-92     Citation Subset:  IM    
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MeSH Terms
Calcinosis / complications*,  metabolism
Hypertension / etiology*,  pathology
Muscle, Smooth, Vascular / metabolism,  pathology*
Tunica Intima / pathology
Tunica Media / pathology
Vascular Diseases / complications*,  metabolism,  pathology
Grant Support
FS/12/16/29384//British Heart Foundation; RG/11/14/29056//British Heart Foundation; //British Heart Foundation

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