Document Detail


Vascular basophilia in ocular and orbital tumors.
MedLine Citation:
PMID:  225286     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The occurrence of vascular basophilia in ocular tumors has been a selective histologic feature of retinoblastomas. We recently observed a metastatic oat-cell carcinoma to the choroid which also demonstrated such a vascular hematoxyphilia. Histologic review of a variety of ocular and orbital metastatic carcinomas failed to yield a similar basophilic pattern. Examination of 100 consecutive retinoblastomas for vascular basophilia revealed an incidence of 6.0%. Similar material was not seen in any of 125 melanomas, including 10 with areas of necrosis. Histochemical studies showed the basophilic material to be DNA, and electron microscopy revealed the nuclear debris of pyknotic tumor cells to be continuous with identical material surrounding the adjacent blood vessels. The pathogenesis of vascular deposition of DNA in these two ocular tumors remains unclear. This finding most likely represents a form of tumor activity requiring comparatively healthy blood vessels to adequately precipitate liberated nucleic acids being filtered from the necrotic and degenerating tumor tissue.
Authors:
G C Stowe; Z N Zakov; D M Albert; T R Smith; D N Sang; J L Craft
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Publication Detail:
Type:  Case Reports; Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Investigative ophthalmology & visual science     Volume:  18     ISSN:  0146-0404     ISO Abbreviation:  Invest. Ophthalmol. Vis. Sci.     Publication Date:  1979 Oct 
Date Detail:
Created Date:  1979-11-29     Completed Date:  1979-11-29     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7703701     Medline TA:  Invest Ophthalmol Vis Sci     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1068-75     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Basophils*
Carcinoma, Small Cell / secondary,  ultrastructure*
Choroid Neoplasms / secondary,  ultrastructure*
DNA, Neoplasm
Eye Neoplasms / secondary,  ultrastructure*
Histological Techniques
Humans
Male
Middle Aged
Muscle, Smooth, Vascular / ultrastructure
Orbital Neoplasms / secondary,  ultrastructure*
Retinoblastoma / ultrastructure
Chemical
Reg. No./Substance:
0/DNA, Neoplasm

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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