Document Detail

Vascular basophilia in ocular and orbital tumors.
MedLine Citation:
PMID:  225286     Owner:  NLM     Status:  MEDLINE    
The occurrence of vascular basophilia in ocular tumors has been a selective histologic feature of retinoblastomas. We recently observed a metastatic oat-cell carcinoma to the choroid which also demonstrated such a vascular hematoxyphilia. Histologic review of a variety of ocular and orbital metastatic carcinomas failed to yield a similar basophilic pattern. Examination of 100 consecutive retinoblastomas for vascular basophilia revealed an incidence of 6.0%. Similar material was not seen in any of 125 melanomas, including 10 with areas of necrosis. Histochemical studies showed the basophilic material to be DNA, and electron microscopy revealed the nuclear debris of pyknotic tumor cells to be continuous with identical material surrounding the adjacent blood vessels. The pathogenesis of vascular deposition of DNA in these two ocular tumors remains unclear. This finding most likely represents a form of tumor activity requiring comparatively healthy blood vessels to adequately precipitate liberated nucleic acids being filtered from the necrotic and degenerating tumor tissue.
G C Stowe; Z N Zakov; D M Albert; T R Smith; D N Sang; J L Craft
Related Documents :
19043576 - Hematopoietic stem cells contribute to lymphatic endothelium.
15509526 - Angiopoietin-1 promotes tumor angiogenesis in a rat glioma model.
15695396 - Ultrasonic imaging of tumor angiogenesis using contrast microbubbles targeted via the t...
11997546 - Differentiation of malignant and benign musculoskeletal tumors: combined color and powe...
22837786 - Primary spinal intramedullary primitive neuroectodermal tumor.
18363516 - Targeted therapies for patients with germ cell tumors.
Publication Detail:
Type:  Case Reports; Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Investigative ophthalmology & visual science     Volume:  18     ISSN:  0146-0404     ISO Abbreviation:  Invest. Ophthalmol. Vis. Sci.     Publication Date:  1979 Oct 
Date Detail:
Created Date:  1979-11-29     Completed Date:  1979-11-29     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7703701     Medline TA:  Invest Ophthalmol Vis Sci     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1068-75     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Carcinoma, Small Cell / secondary,  ultrastructure*
Choroid Neoplasms / secondary,  ultrastructure*
DNA, Neoplasm
Eye Neoplasms / secondary,  ultrastructure*
Histological Techniques
Middle Aged
Muscle, Smooth, Vascular / ultrastructure
Orbital Neoplasms / secondary,  ultrastructure*
Retinoblastoma / ultrastructure
Reg. No./Substance:
0/DNA, Neoplasm

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Growth of diploid, Epstein-Barr virus-carrying human lymphoblastoid cell lines heterotransplanted in...
Next Document:  Adenovirus types 8 and 19 infection of rabbit corneal organ cultures.