Document Detail


Vascular areas where clonidine induces vasodilation in hypertensive and normotensive rats.
MedLine Citation:
PMID:  10622206     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The aim of this study was to find vascular areas where clonidine decreases the regional vascular resistance when this drug lowers arterial pressure in conscious spontaneously hypertensive rats and normotensive control rats. Arterial pressure was observed with an indwelling catheter at a carotid. Blood flow was measured with an electromagnetic flow probe implanted around the renal artery or the superior mesenteric artery. Regional vascular resistance was calculated as arterial pressure divided by blood flow. Intravenous bolus injection of clonidine at a dose to decrease arterial pressure decreased renal resistance and superior mesenteric resistance. Quantitatively, the combined effect of the decrease in these two resistances was enough to account for the decrease in arterial pressure. Although clonidine is thought to inhibit sympathetic nerve activity centrally, the above vasodilator effect is not ascribable to this inhibitory mechanism: Sympathetic activity to be inhibited does not seem to be present in the superior mesenteric area and clonidine similarly decreased renal vascular resistance even after renal denervation.
Authors:
J Iriuchijima
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Tohoku journal of experimental medicine     Volume:  189     ISSN:  0040-8727     ISO Abbreviation:  Tohoku J. Exp. Med.     Publication Date:  1999 Sep 
Date Detail:
Created Date:  2000-02-03     Completed Date:  2000-02-03     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0417355     Medline TA:  Tohoku J Exp Med     Country:  JAPAN    
Other Details:
Languages:  eng     Pagination:  29-36     Citation Subset:  IM    
Affiliation:
Physiological Laboratory, Hiroshima Prefectural College of Health and Welfare, Mihara, Japan. iriuti@hpc.ac.jp
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MeSH Terms
Descriptor/Qualifier:
Animals
Carotid Arteries / drug effects*
Clonidine / pharmacology*
Hypertension / drug therapy
Kidney / blood supply*,  innervation
Mesenteric Artery, Superior / drug effects*
Rats
Rats, Inbred SHR
Rats, Wistar
Renal Blood Flow, Effective / drug effects
Vasodilation / drug effects
Vasodilator Agents / pharmacology*
Chemical
Reg. No./Substance:
0/Vasodilator Agents; 4205-90-7/Clonidine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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