| Vascular angiotensin pathways: a new therapeutic target. | |
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MedLine Citation:
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PMID: 2485070 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The renin-angiotensin system affects blood pressure and regional blood flow through endocrine, paracrine, and autocrine influences. The circulating endocrine renin-angiotensin system (RAS) is activated for acute cardiovascular homeostasis. The recent demonstration of a local renin-angiotensin system in the blood vessel wall has led us to speculate that the local production of angiotensin is involved with autocrine and paracrine control of vascular resistance. In addition to producing arteriolar constriction, arterial wall renin-angiotensin may influence the compliance of large conduit arteries. The production of angiotensin in the blood vessels may participate in hypertension and may influence blood pressure responses to the inhibitors of the RAS. |
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Authors:
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V J Dzau |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.; Review |
Journal Detail:
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Title: Journal of cardiovascular pharmacology Volume: 10 Suppl 7 ISSN: 0160-2446 ISO Abbreviation: J. Cardiovasc. Pharmacol. Publication Date: 1987 |
Date Detail:
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Created Date: 1991-10-01 Completed Date: 1991-10-01 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 7902492 Medline TA: J Cardiovasc Pharmacol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: S9-16 Citation Subset: IM |
Affiliation:
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Division of Vascular Medicine and Atherosclerosis, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Angiotensin II
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biosynthesis,
metabolism,
physiology* Arteries / metabolism Blood Vessels / physiology* Homeostasis / physiology Humans Renin-Angiotensin System / drug effects, physiology* Vascular Resistance |
| Grant Support | |
ID/Acronym/Agency:
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HL 35610/HL/NHLBI NIH HHS; HL 35792/HL/NHLBI NIH HHS; HL35252/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
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11128-99-7/Angiotensin II |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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