| Vascular aging: from molecular mechanism to clinical significance. | |
| | |
MedLine Citation:
|
PMID: 20590836 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
The large and medium-sized arteries in elderly people show varying degrees of intimal and medial change. The medial change is known as age-related medial degeneration and sclerosis (ARMDS). The ARMDS results in systolic hypertension and left ventricular hypertrophy of the heart as a result of loss of arterial elasticity. It also causes aortic dilatation, or even aortic aneurysm. The ARMDS and atherosclerosis are distinct entities, but are often overlapped and confused with each other. The present review mainly focuses on ARMDS and briefly addresses atherosclerosis, and aging of arterioles, capillaries and veins. The smooth muscle cells in the inner half of the aortic media of elderly people degenerate and undergo apoptosis. This causes degradation of elastin fibers and the accumulation of collagen fibers in the media, but the inflammatory infiltrates are scarce. Biochemical studies showed an age-related decrease of elastin and its crosslinks, and an increase of collagen and its crosslink. Because the turnover of elastin is very long, it likely suffers from glycation (Maillard reaction) and glyco-oxidative reaction. The advanced glycation end-products accumulate in the aortic media with increasing age. Alcian-blue positive mucin accumulates in aortic media in elderly people. The major component of the increase of aortic mucin is chondroitin-6-sulfate. Microcalcification is frequent in the inner acellular portion of the aortic media in elderly people. Calcium contents increase with age. In conclusion, the ARMDS is a distinct pathological entity with clinical significance. The pathogenesis of ARMDS is unclear; the mechanical stress of elastin, endothelial dysfunction, and glycation of elastin are proposed. |
| | |
Authors:
|
Motoji Sawabe |
Related Documents
:
|
11009436 - Transarterial wall oxygen gradients at the deployment site of an intra-arterial stent i... 17574586 - Plasmin inhibition increases mmp-9 activity and decreases vein wall stiffness during ve... 20123196 - Evolution of shear stress, protein expression, and vessel area in an animal model of ar... 9391856 - Arterial wall neovascularization--potential role in atherosclerosis and restenosis. 19814726 - Dysfunction of endothelial and smooth muscle cells in small arteries of a mouse model o... 7283516 - Aortopulmonary septal defect: hemodynamics, angiography, and operation. |
Publication Detail:
|
Type: Journal Article; Review |
Journal Detail:
|
Title: Geriatrics & gerontology international Volume: 10 Suppl 1 ISSN: 1447-0594 ISO Abbreviation: Geriatr Gerontol Int Publication Date: 2010 Jul |
Date Detail:
|
Created Date: 2010-07-01 Completed Date: 2010-10-21 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 101135738 Medline TA: Geriatr Gerontol Int Country: Japan |
Other Details:
|
Languages: eng Pagination: S213-20 Citation Subset: IM |
Affiliation:
|
Department of Pathology and Bioresource Center for Geriatric Research, Tokyo Metropolitan Geriatric Hospital and Institute of Gerontology, Tokyo, Japan. sawabe@tmig.or.jp |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Aging
/
physiology Arterial Occlusive Diseases / pathology Arteries / pathology* Atherosclerosis / complications, pathology Capillaries / pathology Collagen / metabolism Dilatation, Pathologic Disease Progression Elasticity Elastin / metabolism Endothelium, Vascular / pathology Glycosaminoglycans / metabolism Glycosylation End Products, Advanced Humans Immunohistochemistry Microfibrils / metabolism Sclerosis Tunica Media / metabolism, pathology* |
| Chemical | |
Reg. No./Substance:
|
0/Glycosaminoglycans; 0/Glycosylation End Products, Advanced; 9007-34-5/Collagen; 9007-58-3/Elastin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Role of methylation of the hMLH1 gene promoter in the development of gastric and colorectal carcinom...
Next Document: Mitochondrial haplogroups associated with lifestyle-related diseases and longevity in the Japanese p...