| Vascular and adrenocortical responses to a specific antagonist of angiotensin II. | |
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MedLine Citation:
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PMID: 1147000 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Angiotensin II receptors in vascular smooth muscle and adrenal cortex have been characterized in the dog. The evidence was derived chiefly from experiments that assessed the ability of a structural analog of angiotensin II, [Sar1, Ile8] AII, to antagonize the effects of exogenously administered angiotensin II on arterial pressure and aldosterone secretion. [Sar1, Ile8] AII is a potent and specific blocker of the pressor response to angiotensinII; in the adrenal cortex, it is a much less effective inhibitor of aldosterone biosynthesis. These results indicate differences in the receptor sites for angiotensin II in vascular smooth muscle and adrenal cortex. Further, they raise the possibility that angiotensin II stimulates aldosterone secretion by mechanisms other than have already been proposed. |
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Authors:
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E L Bravo; M C Khosla; F M Bumpus |
Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: The American journal of physiology Volume: 228 ISSN: 0002-9513 ISO Abbreviation: Am. J. Physiol. Publication Date: 1975 Jan |
Date Detail:
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Created Date: 1975-09-13 Completed Date: 1975-09-13 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 0370511 Medline TA: Am J Physiol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 110-4 Citation Subset: IM |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adrenal Cortex
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metabolism* Adrenal Glands / blood supply, metabolism* Aldosterone / secretion Angiotensin II / analogs & derivatives, antagonists & inhibitors, metabolism* Animals Blood Pressure / drug effects Chemoreceptor Cells* Dexamethasone / pharmacology Dogs Hydrocortisone / secretion Kidney / physiology Male Nephrectomy Potassium / blood Regional Blood Flow Sodium / blood Vasomotor System / metabolism* |
| Chemical | |
Reg. No./Substance:
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11128-99-7/Angiotensin II; 50-02-2/Dexamethasone; 50-23-7/Hydrocortisone; 52-39-1/Aldosterone; 7440-09-7/Potassium; 7440-23-5/Sodium |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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