Document Detail


Vascular actions of arachidonic acid and its metabolites in perfused mesenteric and femoral beds of the dog.
MedLine Citation:
PMID:  350595     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The effects of arachidonate and its major metabolites were examined in vascular beds perfused via the femoral and mesenteric arteries of chloralose-anaesthetised dogs. Close intra-arterial injection of prostacyclin (PGI2, 0.02--2 microgram), PGE2 (0.05--1 microgram) and their precursors, the endoperoxide PGH2 (0.5--2 microgram) and sodium arachidonate (100--550 microgram), all induced vasodilatation. Sodium linoleate (500 microgram) was inactive. Prostacyclin was equally active in both vascular beds, but PGE2 was more potent in the femoral and less so in the mesenteric bed. PGH2 was of similar potency to prostacyclin in both beds, but 6-oxo-PGF 1 alpha (10--100 microgram) was inactive. Thromboxane A2 (TXA2, 1--2 microgram) was a potent vasoconstrictor of the mesenteric bed, but not the femoral bed, although the endoperoxide analogue U46619 was vasocontrictor in both vasculatures. Fatty acid hydroperoxides did not specifically modify the vasodilator effects of PGH2 or arachidonate, presumably because these inhibitors are rapidly reduced in vivo. Indomethacin and meclofenamate potentiated vasodilatation induced by prostacyclin or endoperoxide, but reduced or abolished that caused by arachidonate. The rise in perfusion pressure induced by TXA2 was potentiated and prolonged by indomethacin. Inhibition of synthesis of endogenous prostacyclin, by exacerbating the vasoconstrictor action of TXA2, may have contributed to this effect.
Authors:
G J Dusting; S Moncada; J R Vane
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  European journal of pharmacology     Volume:  49     ISSN:  0014-2999     ISO Abbreviation:  Eur. J. Pharmacol.     Publication Date:  1978 May 
Date Detail:
Created Date:  1978-08-14     Completed Date:  1978-08-14     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  1254354     Medline TA:  Eur J Pharmacol     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  65-72     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Arachidonic Acids / pharmacology*
Dogs
Epoprostenol / pharmacology
Fatty Acids / pharmacology
Female
Femur / blood supply*
Indomethacin / pharmacology
Male
Meclofenamic Acid / pharmacology
Mesentery / blood supply*
Perfusion
Prostaglandins E / pharmacology
Prostaglandins F / pharmacology
Prostaglandins H / pharmacology
Regional Blood Flow / drug effects
Tranylcypromine / pharmacology
Vasoconstrictor Agents
Chemical
Reg. No./Substance:
0/Arachidonic Acids; 0/Fatty Acids; 0/Prostaglandins E; 0/Prostaglandins F; 0/Prostaglandins H; 0/Vasoconstrictor Agents; 155-09-9/Tranylcypromine; 35121-78-9/Epoprostenol; 53-86-1/Indomethacin; 644-62-2/Meclofenamic Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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