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Vascular abnormalities in human newborns with pulmonary hypertension.
MedLine Citation:
PMID:  21510734     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Pulmonary vascular disease embodies all congenital or acquired pathologies that affect the pulmonary vasculature. One of them is pulmonary hypertension of the newborn (PHN), which is clinically characterized by a persistent high pulmonary vascular resistance postnatally and an abnormal vascular response. Morphologically, the vascular walls of the small pulmonary arteries become thickened, leading to increased resistance of these vessels and thus a worsening of gas exchange. PHN occurs as a primary disease or in association with abnormal lung development, for example as in congenital diaphragmatic hernia, and is a critical determinant of morbidity and mortality. Here we review the current knowledge about vascular abnormalities in PHN and discuss the vascular abnormalities in different conditions associated with pulmonary hypertension in human newborns in relation to recent findings from molecular biology.
Authors:
Ilona Sluiter; Irwin Reiss; Ulrike Kraemer; Ronald de Krijger; Dick Tibboel; Robbert J Rottier
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Expert review of respiratory medicine     Volume:  5     ISSN:  1747-6356     ISO Abbreviation:  Expert Rev Respir Med     Publication Date:  2011 Apr 
Date Detail:
Created Date:  2011-04-22     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101278196     Medline TA:  Expert Rev Respir Med     Country:  England    
Other Details:
Languages:  eng     Pagination:  245-56     Citation Subset:  IM    
Affiliation:
Intensive Care and Department of Pediatric Surgery, Erasmus Medical Center-Sophia, Rotterdam, The Netherlands.
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