Document Detail

The vascular hypothesis of Alzheimer's disease: bench to bedside and beyond.
MedLine Citation:
PMID:  20173340     Owner:  NLM     Status:  MEDLINE    
The vascular hypothesis of Alzheimer's disease (AD) which we first proposed in 1993, has become a useful concept in identifying vascular risk factors for AD or vascular dementia that can be modified through appropriate treatment to prevent, reduce or delay the onset of cognitive impairment and dementia onset. Among the more than two dozen vascular risk factors already identified for AD, are cardiovascular disease and carotid artery atherosclerosis, which may exert their pathology by chronically lowering cerebral hypoperfusion during aging. We propose and plan to initiate a clinical study to screen middle-aged, cognitively intact individuals, with carotid artery ultrasound and echocardiography to identify potentially progressive pathology in the heart and carotid artery that is considered modifiable with optimal medical treatment. This clinical strategy, if found effective in preventing pathologic conditions suspected of contributing to severe cognitive impairment, could significantly reduce AD prevalence if applied on a wide scale and help promote healthier mental and physical aging while providing a compelling economic benefit to society.
Jack C de la Torre
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2010-02-18
Journal Detail:
Title:  Neuro-degenerative diseases     Volume:  7     ISSN:  1660-2862     ISO Abbreviation:  Neurodegener Dis     Publication Date:  2010  
Date Detail:
Created Date:  2010-04-14     Completed Date:  2010-07-21     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101189034     Medline TA:  Neurodegener Dis     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  116-21     Citation Subset:  IM    
Copyright Information:
Copyright 2010 S. Karger AG, Basel.
Center for Alzheimer's Research, Banner Sun Health Research Institute, Sun City, AZ 85351, USA.
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MeSH Terms
Alzheimer Disease / epidemiology,  etiology*
Echocardiography / methods
Models, Biological*
Risk Factors
Ultrasonography, Doppler / methods
Vascular Diseases / complications*,  diagnosis

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