| Vascular endothelial growth factor polymorphisms and extent of coronary atherosclerosis in Chinese population with advanced coronary artery disease. | |
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MedLine Citation:
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PMID: 20489684 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Vascular endothelial growth factor (VEGF) is important in atherosclerotic development. We examined two VEGF polymorphisms, including +405 C/G (rs2010963) and -2578C/A (rs699947), to assess their relation to the extent of coronary atherosclerosis. METHODS: We recruited 398 patients with advanced coronary artery disease (CAD). Angiographic "clinical vessel score" (CVS, 1-3 vessels) and "diffuse score" (DS, 0-11.5) were used to evaluate the extent of coronary atherosclerosis. CVS are further categorized into single- (SVD) and multi-vessel disease (MVD: 2 and 3 vessels). Genotyping was performed by TaqMan assay. RESULTS: The frequency of +405 C/G genotype was correlated with CVS and DS (P = 0.016 and 0.016, respectively). The +405C allele frequency was significantly increased in patients with MVD (P = 0.020). The odds ratio (OR) for the CC to the GG genotype was 2.92 (95% confidence interval (CI): 1.31-6.55, P = 0.007). Univariate and logistic regression analysis showed a significant independent association of +405 C/G genotype with SVD/MVD (P = 0.010 and 0.015, respectively) in the recessive model. Furthermore, there is a synergistic effect of CC genotype and diabetes on the occurrence of MVD (P = 0.001 for interaction). There is also a significant independent association of +405 C/G genotype in the recessive model with DS in the uni- and multivariate regression analysis (P = 0.013 and 0.005, respectively). No association was found between VEGF -2578C/A polymorphism and both atherosclerotic parameters. CONCLUSIONS: The VEGF +405C/G polymorphism is a novel genetic factor to influence the extent of coronary atherosclerosis in the Chinese CAD population. |
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Authors:
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Tsung-Hsien Lin; Ho-Ming Su; Chiao-Ling Wang; Wen-Chol Voon; Shyi-Jang Shin; Wen-Ter Lai; Sheng-Hsiung Sheu |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-05-20 |
Journal Detail:
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Title: American journal of hypertension Volume: 23 ISSN: 1941-7225 ISO Abbreviation: Am. J. Hypertens. Publication Date: 2010 Sep |
Date Detail:
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Created Date: 2010-08-24 Completed Date: 2010-12-07 Revised Date: 2011-06-30 |
Medline Journal Info:
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Nlm Unique ID: 8803676 Medline TA: Am J Hypertens Country: United States |
Other Details:
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Languages: eng Pagination: 960-6 Citation Subset: IM |
Affiliation:
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Division of Cardiology, Department of Internal Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aged Asian Continental Ancestry Group / genetics Atherosclerosis / drug therapy, epidemiology, genetics* Comorbidity Coronary Artery Disease / drug therapy, epidemiology, genetics* Diabetes Mellitus / drug therapy, epidemiology, genetics Female Genetic Predisposition to Disease* Humans Hypercholesterolemia / drug therapy, epidemiology, genetics Incidence Male Middle Aged Myocardial Infarction / drug therapy, epidemiology, genetics Polymorphism, Genetic* Prevalence Severity of Illness Index Vascular Endothelial Growth Factors / genetics* |
| Chemical | |
Reg. No./Substance:
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0/Vascular Endothelial Growth Factors |
| Comments/Corrections | |
Comment In:
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Am J Hypertens. 2010 Sep;23(9):938-9
[PMID:
20733573
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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