Document Detail


Vascular endothelial function is not related to serum uric acid in healthy adults.
MedLine Citation:
PMID:  22237152     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Some experimental evidence suggests that uric acid impairs endothelial function. It is controversial if high uric acid levels and impaired endothelial function are related in healthy adults. In addition, the effect of uric acid on endothelial cells (ECs) of humans is unexplored.
METHODS: Data of 107 healthy adult volunteers were analyzed. The association between serum uric acid and endothelial-dependant dilation (EDD) and endothelial-independent dilation (EID) was evaluated by linear regression models. We also examined the relations between uric acid and systemic and cellular markers of inflammation and oxidative stress in all or subsets of participants.
RESULTS: Uric acid levels and EDD were not related in unadjusted or adjusted models. There was a significant negative correlation between uric acid and EID in the pooled sample (r = -0.34, P = 0.005). This correlation remained significant after adjusting for demographics (P = 0.04) and was attenuated after adjusting for other cardiac risk factors (P = 0.12). Higher serum uric acid levels were found to correlate significantly with C-reactive protein (CRP) (r = 0.31, P = 0.002). Serum uric acid levels were not associated with brachial artery EC nuclear factor-κB (NF-κB) p65 or NADPH oxidase p47(phox) expression or with nitrotyrosine staining, but were inversely associated with EC manganese superoxide dismutase (MnSOD) expression (r = -0.5, P = 0.01, n = 25).
CONCLUSION: Elevated serum uric acid is not associated with endothelial dysfunction among healthy adults, but is inversely related to EID and EC MnSOD, and positively related to systemic inflammation. These findings may have implications for cardiovascular risk in healthy adults.
Authors:
Diana I Jalal; Kristen L Jablonski; Kim McFann; Michel B Chonchol; Douglas R Seals
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2012-01-12
Journal Detail:
Title:  American journal of hypertension     Volume:  25     ISSN:  1941-7225     ISO Abbreviation:  Am. J. Hypertens.     Publication Date:  2012 Apr 
Date Detail:
Created Date:  2012-03-19     Completed Date:  2012-07-17     Revised Date:  2014-07-04    
Medline Journal Info:
Nlm Unique ID:  8803676     Medline TA:  Am J Hypertens     Country:  United States    
Other Details:
Languages:  eng     Pagination:  407-13     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Biological Markers / blood
Brachial Artery / physiology*
C-Reactive Protein / metabolism
Endothelium, Vascular / drug effects,  physiopathology*
Female
Humans
Inflammation / blood
Lipoproteins, LDL / blood
Male
Middle Aged
NADPH Oxidase / blood
NF-kappa B / metabolism
Oxidative Stress
Superoxide Dismutase / metabolism
Uric Acid / blood*
Vasodilation / drug effects*
Grant Support
ID/Acronym/Agency:
1K23DK088833-01/DK/NIDDK NIH HHS; AG006537/AG/NIA NIH HHS; AG013038/AG/NIA NIH HHS; AG033994/AG/NIA NIH HHS; F31 AG033994/AG/NIA NIH HHS; K23 DK088833/DK/NIDDK NIH HHS; R01 DK081473-01A1/DK/NIDDK NIH HHS; R01DK078112-01A2/DK/NIDDK NIH HHS; RR025780/RR/NCRR NIH HHS
Chemical
Reg. No./Substance:
0/Biological Markers; 0/Lipoproteins, LDL; 0/NF-kappa B; 0/oxidized low density lipoprotein; 268B43MJ25/Uric Acid; 9007-41-4/C-Reactive Protein; EC 1.15.1.1/Superoxide Dismutase; EC 1.6.3.1/NADPH Oxidase; EC 1.6.3.1/neutrophil cytosolic factor 1
Comments/Corrections

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