Document Detail


Vascular effects of maternal alcohol consumption.
MedLine Citation:
PMID:  22730388     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Maternal alcohol consumption during pregnancy is a significant field of scientific exploration primarily because of its negative effects on the developing fetus, which is specifically defined as fetal alcohol spectrum disorders. Though the effects on the mother are less explored compared with those on the fetus, alcohol produces multiple effects on the maternal vascular system. Alcohol has major effects on systemic hemodynamic variables, endocrine axes, and paracrine factors regulating vascular resistance, as well as vascular reactivity. Alcohol is also reported to have significant effects on the reproductive vasculature including alterations in blood flow, vessel remodeling, and angiogenesis. Data presented in this review will illustrate the importance of the maternal vasculature in the pathogenesis of fetal alcohol spectrum disorders and that more studies are warranted in this field.
Authors:
Jayanth Ramadoss; Ronald R Magness
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Review; Webcasts     Date:  2012-06-22
Journal Detail:
Title:  American journal of physiology. Heart and circulatory physiology     Volume:  303     ISSN:  1522-1539     ISO Abbreviation:  Am. J. Physiol. Heart Circ. Physiol.     Publication Date:  2012 Aug 
Date Detail:
Created Date:  2012-08-16     Completed Date:  2012-10-26     Revised Date:  2013-08-18    
Medline Journal Info:
Nlm Unique ID:  100901228     Medline TA:  Am J Physiol Heart Circ Physiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  H414-21     Citation Subset:  IM    
Affiliation:
Department of Obstetrics and Gynecology, University of Texas Medical Branch, Galveston, TX, USA. jaramado@utmb.edu
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MeSH Terms
Descriptor/Qualifier:
Alcohol Drinking / adverse effects*
Animals
Autonomic Nervous System / drug effects,  metabolism,  physiopathology
Blood Vessels / drug effects*,  metabolism,  physiopathology
Ethanol / adverse effects*
Female
Fetal Alcohol Syndrome / etiology*,  metabolism,  physiopathology
Hemodynamics / drug effects*
Humans
Hypothalamo-Hypophyseal System / drug effects,  metabolism,  physiopathology
Paracrine Communication / drug effects
Placental Circulation / drug effects
Pregnancy
Signal Transduction / drug effects
Grant Support
ID/Acronym/Agency:
AA-19446/AA/NIAAA NIH HHS; HD-38843/HD/NICHD NIH HHS; HL-49210/HL/NHLBI NIH HHS; HL-89144/HL/NHLBI NIH HHS; R00 AA019446/AA/NIAAA NIH HHS
Chemical
Reg. No./Substance:
64-17-5/Ethanol
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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