| Vascular effects of maternal alcohol consumption. | |
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MedLine Citation:
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PMID: 22730388 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Maternal alcohol consumption during pregnancy is a significant field of scientific exploration primarily because of its negative effects on the developing fetus, which is specifically defined as fetal alcohol spectrum disorders. Though the effects on the mother are less explored compared with those on the fetus, alcohol produces multiple effects on the maternal vascular system. Alcohol has major effects on systemic hemodynamic variables, endocrine axes, and paracrine factors regulating vascular resistance, as well as vascular reactivity. Alcohol is also reported to have significant effects on the reproductive vasculature including alterations in blood flow, vessel remodeling, and angiogenesis. Data presented in this review will illustrate the importance of the maternal vasculature in the pathogenesis of fetal alcohol spectrum disorders and that more studies are warranted in this field. |
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Authors:
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Jayanth Ramadoss; Ronald R Magness |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Review; Webcasts Date: 2012-06-22 |
Journal Detail:
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Title: American journal of physiology. Heart and circulatory physiology Volume: 303 ISSN: 1522-1539 ISO Abbreviation: Am. J. Physiol. Heart Circ. Physiol. Publication Date: 2012 Aug |
Date Detail:
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Created Date: 2012-08-16 Completed Date: 2012-10-26 Revised Date: 2013-04-16 |
Medline Journal Info:
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Nlm Unique ID: 100901228 Medline TA: Am J Physiol Heart Circ Physiol Country: United States |
Other Details:
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Languages: eng Pagination: H414-21 Citation Subset: IM |
Affiliation:
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Department of Obstetrics and Gynecology, University of Texas Medical Branch, Galveston, TX, USA. jaramado@utmb.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Alcohol Drinking
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adverse effects* Animals Autonomic Nervous System / drug effects, metabolism, physiopathology Blood Vessels / drug effects*, metabolism, physiopathology Ethanol / adverse effects* Female Fetal Alcohol Syndrome / etiology*, metabolism, physiopathology Hemodynamics / drug effects* Humans Hypothalamo-Hypophyseal System / drug effects, metabolism, physiopathology Paracrine Communication / drug effects Placental Circulation / drug effects Pregnancy Signal Transduction / drug effects |
| Grant Support | |
ID/Acronym/Agency:
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AA-19446/AA/NIAAA NIH HHS; HD-38843/HD/NICHD NIH HHS; HL-49210/HL/NHLBI NIH HHS; HL-89144/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
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64-17-5/Ethanol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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