Document Detail

Vascular Disturbances in Primary Aldosteronism: Clinical Evidence.
MedLine Citation:
PMID:  22890049     Owner:  NLM     Status:  Publisher    
Primary aldosteronism (PA) is a common form of arterial hypertension with a high prevalence of cardiovascular complications. In patients with PA, complex mechanisms may lead to functional and/or structural abnormalities of the blood vessel wall. Clinical evidence indicates that patients with PA may have immune cell activation, increased oxidative stress, impaired endothelial function and vascular remodeling. Activation of fibroproliferation has been found in resistant arteries of patients with PA. Subjects with PA compared to essential hypertensives with similar blood pressure levels have increased intima-media thickness and arterial stiffness as measured by pulse wave velocity. These functional and morphological changes can be modified by an increased sodium intake. Vascular remodeling in PA may indicate a poor response to specific therapy with lower probability of cure and/or normalization of blood pressure. Early diagnosis of PA before blood vessel wall disturbances develop is of utmost importance.
J Widimsky Jr; B Strauch; O Petrák; J Rosa; Z Somloova; T Zelinka; R Holaj
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-8-08
Journal Detail:
Title:  Kidney & blood pressure research     Volume:  35     ISSN:  1423-0143     ISO Abbreviation:  Kidney Blood Press. Res.     Publication Date:  2012 Aug 
Date Detail:
Created Date:  2012-8-14     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9610505     Medline TA:  Kidney Blood Press Res     Country:  -    
Other Details:
Languages:  ENG     Pagination:  529-533     Citation Subset:  -    
Copyright Information:
Copyright © 2012 S. Karger AG, Basel.
Center for Hypertension, 3rd Department of Internal Medicine, Charles University, Prague, Czech Republic.
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