| Vascular conductance is reduced after menthol or cold application. | |
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MedLine Citation:
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PMID: 20818196 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To compare the effects of commercially sold menthol (3.5%) ointment and cold application on blood flow in the forearm. DESIGN: : Prospective counterbalanced design. SETTING: University research laboratory. PARTICIPANTS: Twelve (6 men and 6 women) college-aged students. INTERVENTIONS: Each participant had blood flow measured in the brachial artery for 5 minutes before and 10 minutes after menthol ointment or cold application to the forearm. MAIN OUTCOME MEASURES: Blood velocity, arterial diameter size, and blood pressure were recorded during testing procedures. Vascular conductance was calculated based on these measures and used to describe limb blood flow. RESULTS: We observed a significant reduction (35%; P = 0.004) in vascular conductance within 60 seconds of menthol and cold application to the forearm. Vascular conductance remained significantly reduced for 10 minutes by approximately 19% after both menthol and cold application [F(2.313, 43.594) = 10.328, P < 0.0001]. There was no significant difference between conditions [F(1, 19) = 0.000, P = 0.945]. CONCLUSIONS: The application of a 3.5% menthol ointment significantly reduces conductance in the brachial artery within 60 seconds of application, and this effect is maintained for at least 10 minutes after application. The overall decline in conductance is similar between menthol ointment and cold application. |
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Authors:
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Jennifer L Olive; Brandon Hollis; Elizabeth Mattson; Robert Topp |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Clinical journal of sport medicine : official journal of the Canadian Academy of Sport Medicine Volume: 20 ISSN: 1536-3724 ISO Abbreviation: Clin J Sport Med Publication Date: 2010 Sep |
Date Detail:
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Created Date: 2010-09-06 Completed Date: 2011-01-06 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9103300 Medline TA: Clin J Sport Med Country: United States |
Other Details:
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Languages: eng Pagination: 372-6 Citation Subset: IM |
Affiliation:
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Department of Exercise Science, University of Puget Sound, Tacoma, WA, USA. jenniferolive@yahoo.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Analysis of Variance Antipruritics / adverse effects*, pharmacology Arm / blood supply* Blood Flow Velocity / drug effects Blood Pressure* Brachial Artery Cold Temperature / adverse effects* Female Humans Male Menthol / adverse effects*, pharmacology Ointments / adverse effects, pharmacology Prospective Studies Statistics as Topic Students Universities Young Adult |
| Chemical | |
Reg. No./Substance:
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0/Antipruritics; 0/Ointments; 1490-04-6/Menthol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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