Document Detail

Various heterologous cells exhibit interferon induced transfer of viral resistance.
MedLine Citation:
PMID:  211994     Owner:  NLM     Status:  MEDLINE    
Previously it was shown that cocultivation of mouse L and human WISH or baby hamster kidney cells in the presence of mouse interferon resulted in decreased viral yield from both cell species. We now show that this phenomenon also occurs when rabbit kidney and human WISH cells, with their corresponding interferons, are cocultivated with human WISH and baby hamster kidney cells, respectively. This finding increases the number of donor cell types to three. The related finding that monkey VERO and chick embryo cells can be recipients of transferred resistance expands the number of heterologous recipient cell species capable of receiving transferred resistence to five. Not all cell types tested have been shown to function in this transfer system. The fact that VERO cells, which do not produce interferon, are capable of receiving transferred resistence is significant because it indicates that the mechanism of transfer does not involve production or interferon by the recipient cells.
T K Hughes; J E Blalock; S Baron
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Archives of virology     Volume:  58     ISSN:  0304-8608     ISO Abbreviation:  Arch. Virol.     Publication Date:  1978  
Date Detail:
Created Date:  1978-11-22     Completed Date:  1978-11-22     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  7506870     Medline TA:  Arch Virol     Country:  AUSTRIA    
Other Details:
Languages:  eng     Pagination:  77-80     Citation Subset:  IM    
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MeSH Terms
Cell Line*
Chick Embryo
Immunity, Maternally-Acquired
Interferons / pharmacology*
Species Specificity
Vesicular stomatitis Indiana virus / growth & development*,  immunology
Virus Replication / drug effects
Reg. No./Substance:

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