| Various heterologous cells exhibit interferon induced transfer of viral resistance. | |
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MedLine Citation:
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PMID: 211994 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Previously it was shown that cocultivation of mouse L and human WISH or baby hamster kidney cells in the presence of mouse interferon resulted in decreased viral yield from both cell species. We now show that this phenomenon also occurs when rabbit kidney and human WISH cells, with their corresponding interferons, are cocultivated with human WISH and baby hamster kidney cells, respectively. This finding increases the number of donor cell types to three. The related finding that monkey VERO and chick embryo cells can be recipients of transferred resistance expands the number of heterologous recipient cell species capable of receiving transferred resistence to five. Not all cell types tested have been shown to function in this transfer system. The fact that VERO cells, which do not produce interferon, are capable of receiving transferred resistence is significant because it indicates that the mechanism of transfer does not involve production or interferon by the recipient cells. |
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Authors:
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T K Hughes; J E Blalock; S Baron |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Archives of virology Volume: 58 ISSN: 0304-8608 ISO Abbreviation: Arch. Virol. Publication Date: 1978 |
Date Detail:
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Created Date: 1978-11-22 Completed Date: 1978-11-22 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7506870 Medline TA: Arch Virol Country: AUSTRIA |
Other Details:
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Languages: eng Pagination: 77-80 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cell Line* Chick Embryo Cricetinae Haplorhini Humans Immunity, Maternally-Acquired Interferons / pharmacology* Mice Species Specificity Vesicular stomatitis Indiana virus / growth & development*, immunology Virus Replication / drug effects |
| Chemical | |
Reg. No./Substance:
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9008-11-1/Interferons |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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