Document Detail


Various Viral Compartments in HIV-1-Infected Mothers Contribute to In Utero Transmission of HIV-1.
MedLine Citation:
PMID:  21034247     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Abstract Perinatal HIV transmission occurs in utero or intrapartum. The mechanisms and timing of transmission are not clearly understood. To compare the genetic sequences of the V3 envelope region of infant's plasma HIV to that of the mother's plasma, peripheral blood mononuclear cells (PBMC) and vaginal secretions, and correlate with timing of transmission. All 3 infants had a positive HIV PCR in the first days of life, thus classified as in utero infections. In the first mother-infant pair, two different variants were present in the infant, one correlating with maternal PBMC virus and highly homologous to virus from vaginal secretions and the other identical to sequences in maternal plasma. In the second pair, the infant plasma virus was similar to that of maternal PBMC. In the third pair, the cord blood and infant plasma virus were highly similar to maternal vaginal virus. The presence of more than one HIV variant from the maternal blood and from the vaginal compartment in the cord blood of infants presumably infected in utero could point to more than one episode of transmission or, alternatively, to transmission of PBMC virus.
Authors:
Athena P Kourtis; Angela Martin Amedee; Marc Bulterys; Susan Danner; Russell Van Dyke; Mary Jo O'Sullivan; Robert Maupin; Denise J Jamieson
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Publication Detail:
Type:  Journal Article     Date:  2010-10-29
Journal Detail:
Title:  AIDS research and human retroviruses     Volume:  27     ISSN:  1931-8405     ISO Abbreviation:  AIDS Res. Hum. Retroviruses     Publication Date:  2011 Apr 
Date Detail:
Created Date:  2011-04-04     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8709376     Medline TA:  AIDS Res Hum Retroviruses     Country:  United States    
Other Details:
Languages:  eng     Pagination:  421-7     Citation Subset:  IM; X    
Affiliation:
1 Division of Reproductive Health, National Center for Chronic Disease Prevention and Health Promotion , Atlanta, Georgia .
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