Document Detail

Varicose veins: role of mechanotransduction of venous hypertension.
MedLine Citation:
PMID:  22489273     Owner:  NLM     Status:  In-Data-Review    
Varicose veins affect approximately one-third of the adult population and result in significant psychological, physical, and financial burden. Nevertheless, the molecular pathogenesis of varicose vein formation remains unidentified. Venous hypertension exerted on veins of the lower extremity is considered the principal factor in varicose vein formation. The role of mechanotransduction of the high venous pressure in the pathogenesis of varicose vein formation has not been adequately investigated despite a good progress in understanding the mechanomolecular mechanisms involved in transduction of high blood pressure in the arterial wall. Understanding the nature of the mechanical forces, the mechanosensors and mechanotransducers in the vein wall, and the downstream signaling pathways will provide new molecular targets for the prevention and treatment of varicose veins. This paper summarized the current understanding of mechano-molecular pathways involved in transduction of hemodynamic forces induced by blood pressure and tries to relate this information to setting of venous hypertension in varicose veins.
Hussein M Atta
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Publication Detail:
Type:  Journal Article     Date:  2012-02-12
Journal Detail:
Title:  International journal of vascular medicine     Volume:  2012     ISSN:  2090-2832     ISO Abbreviation:  Int J Vasc Med     Publication Date:  2012  
Date Detail:
Created Date:  2012-04-10     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101542608     Medline TA:  Int J Vasc Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  538627     Citation Subset:  -    
Department of Surgery, Faculty of Medicine, Minia University, Misr-Aswan Road, El-Minia 61519, Egypt.
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