| Varicella-zoster virus vasculopathy and central nervous system immune reconstitution inflammatory syndrome with human immunodeficiency virus infection treated with steroids. | |
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MedLine Citation:
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PMID: 19444693 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Immune reconstitution inflammatory syndrome (IRIS) is widely recognized and rarely involves the central nervous system (CNS). Patients with acquired immunodeficiency syndrome (AIDS) are at an increased risk for developing CNS-IRIS upon initiation of highly active antiretroviral therapy (HAART). This syndrome can be fatal and requires extreme vigilance in determining if a treatable underlying opportunistic infection exists. We report here a case of varicella-zoster virus (VZV) vasculopathy and CNS-IRIS in a human immunodeficiency virus (HIV)-infected patient who required prolonged steroid treatment for clinical stabilization. There are no established treatment regimens for IRIS and the use of corticosteroids in this syndrome remains controversial. Similar to our patient, severe cases of CNS-IRIS may benefit from high-dose intravenous corticosteroid treatment followed by an oral prednisone taper. |
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Authors:
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Scott D Newsome; Avindra Nath |
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Publication Detail:
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Type: Case Reports; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of neurovirology Volume: 15 ISSN: 1538-2443 ISO Abbreviation: J. Neurovirol. Publication Date: 2009 May |
Date Detail:
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Created Date: 2010-07-02 Completed Date: 2010-10-06 Revised Date: 2011-03-29 |
Medline Journal Info:
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Nlm Unique ID: 9508123 Medline TA: J Neurovirol Country: England |
Other Details:
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Languages: eng Pagination: 288-91 Citation Subset: IM |
Affiliation:
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Department of Neurology, Johns Hopkins University School of Medicine, Baltimore 21287, Maryland, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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AIDS-Related Opportunistic Infections
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complications*,
drug therapy Adult Anti-HIV Agents / therapeutic use Anti-Inflammatory Agents / therapeutic use* Antiretroviral Therapy, Highly Active DNA, Viral / cerebrospinal fluid Encephalitis, Varicella Zoster / etiology* Female HIV-1* Herpesvirus 3, Human / genetics, isolation & purification* Humans Immune Reconstitution Inflammatory Syndrome / drug therapy* Methylprednisolone / therapeutic use* Vasculitis, Central Nervous System / etiology* |
| Grant Support | |
ID/Acronym/Agency:
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R01 NS056884/NS/NINDS NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Anti-HIV Agents; 0/Anti-Inflammatory Agents; 0/DNA, Viral; 83-43-2/Methylprednisolone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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