| Varicella-zoster virus infection in adult patients after unrelated cord blood transplantation: a single institute experience in Japan. | |
| | |
MedLine Citation:
|
PMID: 12930392 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Varicella-zoster virus (VZV) infection was studied in 40 adult patients who underwent cord blood transplantation (CBT) from unrelated donors. Twenty-five patients developed VZV reactivation at a median of 5 months after CBT (range 1.7-26 months). The cumulative incidence of VZV reactivation after CBT was 80% at 30 months. Twenty-two patients developed localized herpes zoster. The remaining three patients developed atypical non-localized herpes zoster, which was associated with visceral dissemination in one patient. All the patients responded well to antiviral therapy. Unexpectedly, the absence of grade II-IV acute graft-versus-host disease (GVHD) was associated with a higher rate of VZV reactivation after CBT (100% versus 55%, P=0.01). These results suggest that recovery of VZV-specific immune responses after CBT is delayed even in patients without severe acute GVHD. |
| | |
Authors:
|
Akira Tomonari; Tohru Iseki; Satoshi Takahashi; Jun Ooi; Kashiya Takasugi; Yoko Shimohakamada; Nobuhiro Ohno; Fumitaka Nagamura; Kaoru Uchimaru; Kenzaburo Tani; Arinobu Tojo; Shigetaka Asano |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: British journal of haematology Volume: 122 ISSN: 0007-1048 ISO Abbreviation: Br. J. Haematol. Publication Date: 2003 Sep |
Date Detail:
|
Created Date: 2003-08-21 Completed Date: 2003-10-27 Revised Date: 2006-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 0372544 Medline TA: Br J Haematol Country: England |
Other Details:
|
Languages: eng Pagination: 802-5 Citation Subset: IM |
Affiliation:
|
Department of Hematology/Oncology, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan. atomonar@ims.u-tokyo.ac.jp |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Acute Disease Acyclovir / therapeutic use Adult Antiviral Agents / therapeutic use Cord Blood Stem Cell Transplantation* Female Follow-Up Studies Graft vs Host Disease Hematologic Diseases / immunology, surgery*, virology Herpes Zoster / drug therapy, immunology* Herpesvirus 3, Human / physiology* Humans Incidence Male Middle Aged Proportional Hazards Models Risk Factors Time Factors Transplantation Conditioning Virus Activation* |
| Chemical | |
Reg. No./Substance:
|
0/Antiviral Agents; 59277-89-3/Acyclovir |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: T-cell receptor excision circles: a novel prognostic parameter for the outcome of transplantation in...
Next Document: Effective graft-versus-leukaemia effect after allogeneic stem cell transplantation using reduced-int...