Document Detail


Varicella in the fetus and newborn.
MedLine Citation:
PMID:  19097954     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Varicella (chickenpox) in pregnancy is unusual because most women of childbearing age are immune. It can, however, cause significant morbidity for the pregnant woman and in rare cases cause congenital varicella syndrome. The incidence of congenital varicella syndrome after maternal varicella during the first two trimesters is <1% across multiple cohort studies. Maternal infection in the third trimester is not associated with congenital varicella syndrome, but the infant may develop herpes zoster during the first one or two years. Maternal infection just before or after delivery presents a high risk for disseminated varicella in the infant. Serious infection can be prevented with passive antibody prophylaxis and antiviral therapy. Maternal herpes zoster does not result in adverse fetal or neonatal outcomes.
Authors:
Candice K Smith; Ann M Arvin
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Publication Detail:
Type:  Journal Article; Review     Date:  2008-12-19
Journal Detail:
Title:  Seminars in fetal & neonatal medicine     Volume:  14     ISSN:  1878-0946     ISO Abbreviation:  -     Publication Date:  2009 Aug 
Date Detail:
Created Date:  2009-06-05     Completed Date:  2009-10-27     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101240003     Medline TA:  Semin Fetal Neonatal Med     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  209-17     Citation Subset:  IM    
Affiliation:
Stanford University School of Medicine, 300 Pasteur Drive, G322, Stanford, CA 94305, USA. candices@stanford.edu
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MeSH Terms
Descriptor/Qualifier:
Antiviral Agents / therapeutic use
Chickenpox / drug therapy,  transmission*
Disease Transmission, Infectious
Female
Humans
Infant, Newborn
Infectious Disease Transmission, Vertical*
Pregnancy
Pregnancy Complications, Infectious*
Pregnancy Outcome*
Risk Factors
Chemical
Reg. No./Substance:
0/Antiviral Agents

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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