Document Detail

Varicella zoster virus-induced hemolytic crisis in an infant with severe vitamin B 12 deficiency.
MedLine Citation:
PMID:  20445420     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Vitamin B 12 deficiency is an uncommon disorder in infancy. Most cases are because of maternal deficiency resulting from insufficient storage and/or reduced intake and are generally seen in exclusively breast-fed infants. Accentuation of the hemolytic process has never been described in association with Varicella Zoster Virus (VZV) infections.
OBSERVATION: We describe a 9-months-old breast-fed infant with megaloblastic anemia secondary to maternal vitamin B 12 deficiency. He presented severe pancytopenia and regression of motor functions and developed hemolytic crisis during a VZV infection.
CONCLUSIONS: Nutritional cobalamin deficiency should be considered in anemic infants with a history of prolonged exclusive breastfeeding and delayed developmental milestones. VZV infection can trigger a hemolytic process in infants with severe megaloblastic anemia secondary to B12 deficiency. A normal mean corpuscular volume does not rule out megaloblastic anemia, when the condition is combined with severe hemolysis.
Francesca Lombardi; Anna Lucia Quitadamo; Lucia Dora Notarangelo; Alessandra Pelizzoni; Paola Accorsi; Franco Olivetti; Richard Fabian Schumacher
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of pediatric hematology/oncology     Volume:  32     ISSN:  1536-3678     ISO Abbreviation:  J. Pediatr. Hematol. Oncol.     Publication Date:  2010 May 
Date Detail:
Created Date:  2010-05-06     Completed Date:  2010-05-27     Revised Date:  2011-10-06    
Medline Journal Info:
Nlm Unique ID:  9505928     Medline TA:  J Pediatr Hematol Oncol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  317-8     Citation Subset:  IM    
UOC of Pediatrics, AO Carlo Poma, Pieve di Coriano, Mantova, Italy.
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MeSH Terms
Herpes Zoster / therapy,  virology*
Herpesvirus 3, Human / pathogenicity*
Pancytopenia / therapy,  virology*
Treatment Outcome
Vitamin B 12 Deficiency / complications*

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