Document Detail

Variations on a theme: the many modes of cytokinesis.
MedLine Citation:
PMID:  15037305     Owner:  NLM     Status:  MEDLINE    
Animal cell division is believed to be mediated primarily by the 'purse-string' mechanism, which entails furrowing of the equatorial region, driven by the interaction of actin and myosin II filaments within contractile rings. However, myosin II-null Dictyostelium cells on substrates divide efficiently in a cell cycle-coupled manner. This process, termed cytokinesis B, appears to be driven by polar traction forces. Data in the literature can be interpreted as suggesting that adherent higher animal cells also use a cytokinesis B-like mechanism for cytokinesis. An additional chemotaxis-based cytokinesis that involves a 'midwife' cell has also been reported. Collectively, these findings demonstrate an unexpected diversity of mechanisms by which animal cells carry out cytokinesis.
Taro Q P Uyeda; Akira Nagasaki
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Current opinion in cell biology     Volume:  16     ISSN:  0955-0674     ISO Abbreviation:  Curr. Opin. Cell Biol.     Publication Date:  2004 Feb 
Date Detail:
Created Date:  2004-03-23     Completed Date:  2004-10-14     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  8913428     Medline TA:  Curr Opin Cell Biol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  55-60     Citation Subset:  IM    
Gene Function Research Center, Tsukuba Central 4, AIST, Tsukuba, Ibaraki 305-8562, Japan.
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MeSH Terms
Cell Division / physiology*
Cell Movement
Dictyostelium / cytology,  genetics
Nonmuscle Myosin Type IIB / physiology
Reg. No./Substance:
EC 3.6.1.-/Nonmuscle Myosin Type IIB

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