Document Detail

Variations of plasma enzymes in the pony and the dog after carbon tetrachloride administration.
MedLine Citation:
PMID:  7332128     Owner:  NLM     Status:  MEDLINE    
Adult female dogs or pony mares were subjected to a nonlethal dose of CCl4 (0.5 ml/kg of body weight). Amounts of several plasma enzymes thought to be indicative of hepatic disease were monitored. Plasma enzymes alanine aminotransferase, aspartate aminotransferase (AST), alkaline phosphatase (ALP), arginase, gamma-glutamyltransferase (GGT), and iditol dehydrogenase (ID), as well as total plasma bilirubin, were determined in these animals before and after the administration of the CCl4. In the dog, GGT was not significantly increased, whereas ALP values were increased during days 1 to 6. In the pony, GGT was significantly increased during the entire course of the study, whereas ALP exhibited only small, transient (though significant) increases. Responses of ID, AST, and ALP were unremarkable when compared between the pony and the dog. Total bilirubin was significantly (P less than or equal to 0.05) increased from days 1 to 4 (pony) or days 5 to 8 (dog) after the CCl4 dose, but subsequently returned to or decreased below base-line values. Animals did not have evidence of icterus at any time. Seemingly, the dog and the pony are distinct clinical entities, and only the appropriate laboratory tests for each species should be used to provide information for the clinicopathologic evaluation of hepatic disease.
N E Noonan
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  American journal of veterinary research     Volume:  42     ISSN:  0002-9645     ISO Abbreviation:  Am. J. Vet. Res.     Publication Date:  1981 Apr 
Date Detail:
Created Date:  1982-04-12     Completed Date:  1982-04-12     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0375011     Medline TA:  Am J Vet Res     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  674-8     Citation Subset:  IM    
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MeSH Terms
Alkaline Phosphatase / blood
Arginase / blood
Bilirubin / blood
Carbon Tetrachloride / pharmacology*
Dog Diseases / enzymology
Dogs / metabolism*
Horse Diseases / enzymology
Horses / metabolism*
L-Iditol 2-Dehydrogenase / blood
Liver / drug effects*,  enzymology
Liver Diseases / enzymology,  veterinary
Transferases / blood
Reg. No./Substance:
56-23-5/Carbon Tetrachloride; 635-65-4/Bilirubin; EC 2-Dehydrogenase; EC 2.-/Transferases; EC Phosphatase; EC

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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