Document Detail

Variations in platelet 5-hydroxytryptamine in control and depressed populations.
MedLine Citation:
PMID:  3806429     Owner:  NLM     Status:  MEDLINE    
Platelet 5-hydroxytryptamine uptake was measured in a group of 28 endogenously depressed patients at three points during the day, before, during and after treatment and in 20 controls at the same three times. Uptake rates varied in control subjects in a manner consistent with the presence of a circadian rhythm in uptake. This variation was absent in depressed subjects. Normal variation was restored in those patients showing a clinical response, irrespective of the effects of treatment on the affinity of the uptake system. This restoration was not found in nonresponders or acutely after treatment was commenced. These findings suggest that depression is associated with a disruption of circadian rhythms, that abnormalities of platelet 5-hydroxytryptamine uptake are secondary to such a disruption and that antidepressants may act to correct this disruption.
D Healy; A O'Halloran; P A Carney; B E Leonard
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of psychiatric research     Volume:  20     ISSN:  0022-3956     ISO Abbreviation:  J Psychiatr Res     Publication Date:  1986  
Date Detail:
Created Date:  1987-03-11     Completed Date:  1987-03-11     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0376331     Medline TA:  J Psychiatr Res     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  345-53     Citation Subset:  IM    
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MeSH Terms
Blood Platelets / analysis*
Combined Modality Therapy
Depressive Disorder / blood*,  therapy
Dothiepin / therapeutic use
Electroconvulsive Therapy
Mianserin / therapeutic use
Middle Aged
Serotonin / blood*
Trazodone / therapeutic use
Reg. No./Substance:
113-53-1/Dothiepin; 19794-93-5/Trazodone; 24219-97-4/Mianserin; 50-67-9/Serotonin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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