Document Detail

Variations in the frequency of fetal hemoglobin-bearing erythrocytes (F-cells) in well adults, pregnant women, and adult leukemics.
MedLine Citation:
PMID:  810611     Owner:  NLM     Status:  MEDLINE    
Fetal hemoglobin (HbF) in adult life is usually restricted to a few erythrocytes called F-cells. Their presence can be detected and the quantity of HbF per F-cell estimated by pericellular immunodiffusion reactions with anti-HbF. In normal adults F-cell frequency (range: 1 F-cell per 25 erythrocytes to 1 per 6800) and the mean amount of HbF per F-cell (range: approximately 14 to 28% of mean cell hemoglobin), although they are variables, remain constant over many months. Frequencies are similar in men and women. For a given individual, F-cell lifetimes are probably similar to those of other erythrocytes. F-cell production is not appreciably influenced by short term exposure to high altitude (approximately 4300 m) hypoxia. F-cell frequencies are briefly but substantially increased in many women during midpregnancy. In some women, presumptive 5- to 15-fold increases in F-cell production result in observed 3- to 7-fold increases in F-cell frequency during the 23rd to 31st weeks of gestation. These increases in F-cell frequency arise from selective alterations in maternal erythropoiesis and not from transplacental bleeding from the fetus. Substantial increases in F-cell frequency also occur in most adults with acute leukemia. In both pregnancy and leukemia, F-cell contributions of HbF are sufficient to account for modest elevations found in hemolysate HbF levels.
S H Boyer; T K Belding; L Margolte; A N Noyes; P J Burke; W R Bell
Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The Johns Hopkins medical journal     Volume:  137     ISSN:  0021-7263     ISO Abbreviation:  Johns Hopkins Med J     Publication Date:  1975 Sep 
Date Detail:
Created Date:  1976-01-08     Completed Date:  1976-01-08     Revised Date:  2009-11-11    
Medline Journal Info:
Nlm Unique ID:  0072456     Medline TA:  Johns Hopkins Med J     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  105-15     Citation Subset:  IM    
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MeSH Terms
Age Factors
Anemia, Aplastic / blood
Anoxia / blood
Cell Survival
Erythrocytes / analysis*
Fetal Hemoglobin / analysis*
Leukemia / blood*
Leukemia, Myeloid / blood
Middle Aged
Sex Factors
Reg. No./Substance:
9034-63-3/Fetal Hemoglobin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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