| Variations in cervical IL-10 and IL-8 concentrations throughout gestation in normal pregnancies. | |
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MedLine Citation:
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PMID: 17501766 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PROBLEM: Data regarding cervical interleukin 18 (IL-8) and IL-10 concentrations during pregnancy is limited. METHOD OF STUDY: This was a cross sectional study of healthy pregnant women. Specimens were collected from the cervical os secretions. IL-8 and IL-10 levels were measured by using enzyme-linked immunosorbent assay. Median (range) cytokine concentrations were derived for each trimester and compared across trimesters. The relationship between gestational age and cytokine levels was assessed by regression analysis. The mean of the ratios of IL-8 to IL-10 was compared in each trimester using anova. RESULTS: The median (range) IL-8 concentrations in cervical secretions were in pg/mL: 1562 (1210-4100), 2460 (1047-4688), 3660 (1451-4748) (P < 0.0021); the median (range) IL-10 concentrations in cervical secretions were in pg/mL: 38.3 (6.8-227.9), 10.9 (0-263.3), 9.5 (0-35.6); the mean IL10/IL-8 x 100 (+/- standard deviation) concentrations were: 3.33 +/- 0.65, 1.47 +/- 0.41, 0.38 +/- 0.52 (P = 0.0035) during the first, second and third trimesters, respectively. CONCLUSION: The patterns of cervical IL-8 concentration is inversely related to gestational age, and the ratio of IL-10/IL-8 decreases with advancing gestation. |
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Authors:
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Myriam Mondestin-Sorrentino; John C Smulian; Anthony M Vintzileos; David Sorrentino; Cande V Ananth; Surendra Sharma; Nazeeh N Hanna |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural |
Journal Detail:
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Title: American journal of reproductive immunology (New York, N.Y. : 1989) Volume: 57 ISSN: 1046-7408 ISO Abbreviation: Am. J. Reprod. Immunol. Publication Date: 2007 Jun |
Date Detail:
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Created Date: 2007-05-15 Completed Date: 2007-08-29 Revised Date: 2007-12-03 |
Medline Journal Info:
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Nlm Unique ID: 8912860 Medline TA: Am J Reprod Immunol Country: Denmark |
Other Details:
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Languages: eng Pagination: 482-7 Citation Subset: IM |
Affiliation:
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Division of Maternal-Fetal Medicine, Department of Obstetrics, Gynecology, Jersey Shore University Medical Center, Neptune, NJ, USA. mondesmy@umdnj.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Analysis of Variance Biological Markers / metabolism Cervix Mucus / chemistry, metabolism* Cross-Sectional Studies Female Humans Interleukin-10 / analysis*, chemistry, metabolism* Interleukin-18 / analysis, chemistry, metabolism* Pregnancy / metabolism* Pregnancy Trimester, First Pregnancy Trimester, Second Pregnancy Trimester, Third United States |
| Grant Support | |
ID/Acronym/Agency:
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R01 HD038902/HD/NICHD NIH HHS; R01 HD41701/HD/NICHD NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Biological Markers; 0/Interleukin-18; 130068-27-8/Interleukin-10 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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