| Variation within the PPARG gene is associated with residual beta-cell function and glycemic control in children and adolescents during the first year of clinical type 1 diabetes. | |
| | |
MedLine Citation:
|
PMID: 18466209 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
CONTEXT: Conflicting evidence exists as to whether the Pro12Ala single nucleotide polymorphism of the type 2 diabetes susceptibility gene peroxisome proliferator-activated receptor gamma (PPARG) also confers risk for type 1 diabetes (T1D). OBJECTIVE: The objective of this study was to investigate the PPARG gene in relation to residual beta-cell function and glycemic control in newly diagnosed T1D. DESIGN: Prospective, non-interventional, 12-month follow-up study, conducted in 18 centers in 15 countries. PATIENTS: Two hundred and fifty-seven children and adolescents (aged <16 yr) with newly diagnosed T1D. MAIN OUTCOME MEASURES: Beta-cell function was determined as 90-min meal-stimulated C-peptide (Boost test) 1, 6, and 12 months after diagnosis. Hemoglobin A1c (HbA1c) and daily insulin dose (IU/kg/d) were recorded at 1, 3, 6, 9, and 12 months after diagnosis. Haplotypes within PPARG were estimated by SNPHap program. Statistical analyses were performed in a repeated measurements model. RESULTS: Five haplotypes within PPARG were generated (h1, 68.4%; h2, 16.3%; h3, 8.3%; h4, 3.5%; and hx, 3.5%). Compared with the most frequent h1 haplotype, the haplotypes h3 and h4 of the PPARG associated with residual beta-cell function during the first year of clinical disease: h3 with a 27% lower C-peptide (p = 0.02) and h4 with a 39% lower C-peptide (p = 0.01). Haplotype h4 also associated with a 0.86% (absolute) higher HbA1c, after adjustment for the insulin dose (p = 0.02). CONCLUSION: Variation in the PPARG locus may influence disease progression during the first year after the presentation of T1D. |
| | |
Authors:
|
Sven Pörksen; Lotte B Nielsen; Henrik B Mortensen; Thomas Danne; Mirjana Kocova; Luis Castaño; Flemming Pociot; Philip Hougaard; Claus T Ekstrøm; Steen Gammeltoft; Mikael Knip; Lars Hansen; |
Related Documents
:
|
20548129 - The role of nitric oxide in airway responsiveness in diabetic-antigen sensitized guinea... 7016719 - On the significance of c2, c4, and factor b polymorphisms in disease. 3878699 - Immunological monitoring of plasma exchange in primary iga nephropathy. 16355419 - The relevance of international consortia in studies on the pathogenesis of type 1 diabe... 18565729 - T-cell reactivity to insulin peptide a1-12 in children with recently diagnosed type 1 d... 8200299 - Analysis of the contribution of the hla system to the inheritance in the wolfram syndrome. 15793259 - The exon 1 cys7gly polymorphism within the betacellulin gene is associated with type 2 ... 21719559 - Systematic kidney disease management in a population with diabetes mellitus: turning th... 1936059 - Radiorespirometric patterns of [14c]-substrates in rats. ii. differences with the natur... |
Publication Detail:
|
Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't Date: 2008-05-07 |
Journal Detail:
|
Title: Pediatric diabetes Volume: 9 ISSN: 1399-5448 ISO Abbreviation: Pediatr Diabetes Publication Date: 2008 Jul |
Date Detail:
|
Created Date: 2008-09-04 Completed Date: 2009-02-03 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 100939345 Medline TA: Pediatr Diabetes Country: Denmark |
Other Details:
|
Languages: eng Pagination: 297-302 Citation Subset: IM |
Affiliation:
|
Department of Pediatrics, Glostrup University Hospital, Glostrup, Denmark. svepor01@glo.regionh.dk |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adolescent Blood Glucose / metabolism Child Diabetes Mellitus, Type 1 / genetics* Disease Progression* Female Follow-Up Studies Humans Insulin-Secreting Cells / physiology* Male PPAR gamma / genetics, metabolism* Time Factors |
| Chemical | |
Reg. No./Substance:
|
0/Blood Glucose; 0/PPAR gamma |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Thyroid autoimmunity in children with features of both type 1 and type 2 diabetes.
Next Document: Effects of insulin pump vs. injection treatment on quality of life and impact of disease in children...