| Variation of serum IgG subclass concentrations with disease activity in juvenile chronic arthritis. | |
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MedLine Citation:
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PMID: 2774699 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Nineteen patients with juvenile chronic arthritis were followed up and serum IgG subclass concentrations measured at different stages of disease activity. Patients were divided into three groups according to clinical activity of the disease: active disease, partial remission, and remission. The results were compared with normal values obtained in 448 healthy children aged 6 months to 18 years with a homogeneous distribution for each year of age. Serum IgG subclass concentrations of each child were first log transformed and then age corrected, taking the deviation of the log transformed value from that expected for a child of the same age. It was found that patients with partial remission had increased concentrations of IgG2 and decreased concentrations of IgG1 compared with patients with active disease. This suggests that the remission inducing process, at least in juvenile chronic arthritis, is accompanied by a switch of IgG subclass production. |
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Authors:
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A Martini; M A Avanzini; A Ravelli; L Zonta; A Plebani; F de Benedetti; R G Burgio |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Annals of the rheumatic diseases Volume: 48 ISSN: 0003-4967 ISO Abbreviation: Ann. Rheum. Dis. Publication Date: 1989 Jul |
Date Detail:
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Created Date: 1989-09-27 Completed Date: 1989-09-27 Revised Date: 2009-11-18 |
Medline Journal Info:
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Nlm Unique ID: 0372355 Medline TA: Ann Rheum Dis Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 582-5 Citation Subset: IM |
Affiliation:
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Department of Pediatrics, University of Pavia, Italy. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Arthritis, Juvenile Rheumatoid / immunology* Child Child, Preschool Female Humans Immunoglobulin G / analysis, classification* Infant Male Severity of Illness Index |
| Chemical | |
Reg. No./Substance:
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0/Immunoglobulin G |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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