Document Detail

Variation of postprandial PYY 3-36 response following ingestion of differing macronutrient meals in obese females.
MedLine Citation:
PMID:  18544972     Owner:  NLM     Status:  MEDLINE    
AIM: This study investigated the effect of macronutrient composition of meals on postprandial peptide YY(3-36) (PYY(3-36)) response in obese hyperinsulinemic females. METHODS: Eight obese females consumed three iso-energetic meals of different macronutrient composition, high carbohydrate (HC; 60% CHO, 20% protein, 20% fat), high fat (HF; 30% CHO, 20% protein, 50% fat) and high protein (HP; 30% CHO, 50% protein, 20% fat), on three separate occasions, 1 month apart. PYY(3-36), insulin and glucose were measured before and 15, 30, 60, 120 and 180 min following each meal. RESULTS: PYY(3-36) levels increased significantly following the three meals, with the HC meal resulting in a sustained postprandial increase in PYY(3-36) level throughout the experimental period. Comparing the three meals, the HF meal induced a significantly higher increase in postprandial PYY(3-36) levels, at 15 and 30 min as compared to the HP meal (p < 0.05), whereas the postprandial increase following the HP meal became significantly higher than that following the HF meal at 120 min. Postprandial increase in PYY(3-36) was highest in the first hour following the HF meal, while that following the HP meal was delayed by 1 h. CONCLUSION: Increasing both protein and fat content of a meal may induce an immediate and prolonged increase in PYY(3-36), resulting in increased satiety and its maintenance for a longer period of time.
Nancy Helou; Omar Obeid; Sami T Azar; Nahla Hwalla
Publication Detail:
Type:  Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't     Date:  2008-06-11
Journal Detail:
Title:  Annals of nutrition & metabolism     Volume:  52     ISSN:  1421-9697     ISO Abbreviation:  Ann. Nutr. Metab.     Publication Date:  2008  
Date Detail:
Created Date:  2008-07-11     Completed Date:  2008-09-03     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8105511     Medline TA:  Ann Nutr Metab     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  188-95     Citation Subset:  IM    
Copyright Information:
(c) 2008 S. Karger AG, Basel.
Department of Nutrition and Food Science, Faculty of Agriculture and Food Sciences, American University of Beirut, Beirut, Lebanon.
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MeSH Terms
Area Under Curve
Blood Glucose / metabolism
Cross-Over Studies
Dietary Carbohydrates / administration & dosage*,  metabolism
Dietary Fats / administration & dosage*,  metabolism
Dietary Proteins / administration & dosage*,  metabolism
Obesity / blood*,  prevention & control
Peptide YY / blood*
Postprandial Period
Satiety Response / drug effects*
Reg. No./Substance:
0/Blood Glucose; 0/Dietary Carbohydrates; 0/Dietary Fats; 0/Dietary Proteins; 106388-42-5/Peptide YY; 123583-37-9/peptide YY (3-36)

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