Document Detail


Variation of levels of plasma guanosine diphosphate L-fucose:beta-D-galactosyl alpha-2-L-fucosyltransferase in acute adult leukemia.
MedLine Citation:
PMID:  872083     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We have measured plasma levels of an alpha-2-L-fucosyltransferase in 18 patients with acute adult leukemia at various clinical stages along with simultaneous bone marrow aspirations and biopsies. Patients in remission had significantly lower levels of this enzyme than did nonresponding or relapsing patients. Furthermore, plasma levels were correlated with percentage of marrow blast cells. This enzyme may serve as a biological marker for monitoring patients with acute leukemia receiving chemotherapy. It is particularly helpful as a guide to chemotherapy in patients on whom bone marrow aspirates are technically difficult to obtain.
Authors:
P Khilanani; T H Chou; P L Lomen; D Kessel
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Cancer research     Volume:  37     ISSN:  0008-5472     ISO Abbreviation:  Cancer Res.     Publication Date:  1977 Aug 
Date Detail:
Created Date:  1977-09-02     Completed Date:  1977-09-02     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  2984705R     Medline TA:  Cancer Res     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  2557-9     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Acute Disease
Adult
Aged
Female
Fucose
Galactose
Guanosine Diphosphate Fucose
Hexosyltransferases / blood*
Humans
Leukemia / blood,  enzymology*
Male
Middle Aged
Chemical
Reg. No./Substance:
15839-70-0/Guanosine Diphosphate Fucose; 26566-61-0/Galactose; 3713-31-3/Fucose; EC 2.4.1.-/Hexosyltransferases

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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