Document Detail

Variation in selenoenzyme genes and prostate cancer risk and survival.
MedLine Citation:
PMID:  23143801     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: While several studies showed that selenium may prevent prostate cancer (PCa), few studies have evaluated variation in selenoenzyme genes in relation to PCa risk and survival.
METHODS: We studied common variants in seven selenoenzymes genes in relation to risk of PCa and PCa-specific mortality (PCSM). In a population-based case-control study of men of European ancestry (1,309 cases, 1,266 controls), we evaluated 35 common, tagging single nucleotide polymorphisms (SNPs) in GPX1 (n = 2), GPX2 (n = 4), GPX3 (n = 6), GPX4 (n = 6), SEP15 (n = 4), SEPP1 (n = 6), and TXNRD1 (n = 7) in relation to PCa risk, and among cases, associations between these variants and risk of PCSM. We used logistic regression and Cox proportional hazards regression to estimate the relative risk of PCa and PCSM, respectively.
RESULTS: Of the SNPs examined, only GPX1 rs3448 was associated with overall PCa risk with an odds ratio of 0.62 for TT versus CC (95% confidence interval, 0.44-0.88). SNPs in GPX2, GPX3, GPX4, SEP15, and SEPP1 had different risk estimates for PCa in subgroups based on stage and grade. We observed associations between SNPs in GPX4, and TXNRD1 and risk of PCSM. None of these associations, however, remained significant after adjustment for multiple comparisons.
CONCLUSIONS: We found evidence that genetic variation in a subset of selenoenzyme genes may alter risk of PCa and PCSM. These results need validation in additional subsets.
Milan S Geybels; Carolyn M Hutter; Erika M Kwon; Elaine A Ostrander; Rong Fu; Ziding Feng; Janet L Stanford; Ulrike Peters
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, N.I.H., Intramural; Research Support, Non-U.S. Gov't     Date:  2012-11-09
Journal Detail:
Title:  The Prostate     Volume:  73     ISSN:  1097-0045     ISO Abbreviation:  Prostate     Publication Date:  2013 May 
Date Detail:
Created Date:  2013-04-15     Completed Date:  2013-06-27     Revised Date:  2014-05-08    
Medline Journal Info:
Nlm Unique ID:  8101368     Medline TA:  Prostate     Country:  United States    
Other Details:
Languages:  eng     Pagination:  734-42     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 Wiley Periodicals, Inc.
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MeSH Terms
Case-Control Studies
Genetic Predisposition to Disease
Genetic Variation
Glutathione Peroxidase / genetics*
Logistic Models
Middle Aged
Polymorphism, Single Nucleotide*
Proportional Hazards Models
Prostatic Neoplasms / genetics*,  mortality*
Risk Factors
Selenium / metabolism*
Grant Support
P50 CA097186/CA/NCI NIH HHS; P50-CA097186/CA/NCI NIH HHS; R01 CA056678/CA/NCI NIH HHS; R01 CA092579/CA/NCI NIH HHS; R01 CA120582/CA/NCI NIH HHS; R01-CA056678/CA/NCI NIH HHS; R01-CA092579/CA/NCI NIH HHS; R01-CA120582/CA/NCI NIH HHS; R03 CA137799/CA/NCI NIH HHS; R03-CA137799/CA/NCI NIH HHS
Reg. No./Substance:
EC Peroxidase; EC glutathione peroxidase; H6241UJ22B/Selenium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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