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Variation in reported neonatal Group B Streptococcal disease incidence in developing countries.
MedLine Citation:
PMID:  22523262     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
BackgroundGroup B Streptococcus (GBS) is a leading cause of neonatal sepsis in developed countries. Its burden in the developing world is less clear.MethodsStudies reporting neonatal GBS disease incidence from developing countries were identified from five literature databases. Studies were assessed with respect to case finding and culture methods.ResultsOnly twenty studies were identified. The GBS incidence ranged from 0-3.06 per 1000 live births with variation within and between geographic regions. All but one study identified GBS cases within a hospital setting despite the potential for births in the community. Possible case under-ascertainment was only discussed in two studies. A higher GBS incidence was reported when using automated culture methods.ConclusionProspective population-based surveillance is urgently needed in developing countries to provide an accurate assessment of the neonatal GBS disease burden. This will be crucial in designing interventions, including novel vaccines, and their potential to impact mortality from neonatal sepsis.
Authors:
Alemnew F Dagnew; Marianne C Cunnington; Queen Dube; Morven S Edwards; Neil French; Robert S Heyderman; Shabir A Madhi; Karen Slobod; Sue Ann Costa Clemens
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-4-20
Journal Detail:
Title:  Clinical infectious diseases : an official publication of the Infectious Diseases Society of America     Volume:  -     ISSN:  1537-6591     ISO Abbreviation:  -     Publication Date:  2012 Apr 
Date Detail:
Created Date:  2012-4-23     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9203213     Medline TA:  Clin Infect Dis     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
College of Health Sciences, Department of Microbiology, Immunology and Parasitology, Mekelle University, Mekelle, Ethiopia.
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