Document Detail

Variation in osteoarthritis biomarkers from activity not food consumption.
MedLine Citation:
PMID:  18727924     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: To optimize sampling and to understand sources of variation in biomarkers for osteoarthritis (OA), we evaluated variation due to activity and food consumption.
METHODS: Twenty participants, with radiographic knee OA, provided serial serum and urine samples at 4 time points: before arising in the morning; after 1 h of light activity; 1 h after eating breakfast; and in the evening. Five serum (s) and 2 urinary (u) analytes were measured: hyaluronan (sHA); cartilage oligomeric matrix protein (sCOMP); keratan sulfate (sKS-5D4); transforming growth factor beta (sTGF-ss1); and collagen II-related epitopes (sCPII, uCTXII, and uC2C). Activity was monitored by an accelerometer.
RESULTS: All serum biomarkers increased and one of the urinary biomarkers decreased after 1 h of non-exertional activity. Food consumption following activity was associated with a return of biomarker concentrations to baseline levels. Accelerometers proved to be a novel way to monitor protocol compliance and demonstrated a positive association between the mean level of activity and sCOMP concentration. Urinary CTXII varied the least but demonstrated both true circadian variation (peak in the morning and nadir in the evening) and the most robust correlation with radiographic knee OA.
CONCLUSIONS: We confirm activity related variation in these markers. These data suggested that biomarkers also varied due to upright posture, glomerular filtration rate stimulated by food intake, and circadian rhythm in the case of uCTXII.
Craig D Gordon; Thomas V Stabler; Virginia B Kraus
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2008-08-05
Journal Detail:
Title:  Clinica chimica acta; international journal of clinical chemistry     Volume:  398     ISSN:  0009-8981     ISO Abbreviation:  Clin. Chim. Acta     Publication Date:  2008 Dec 
Date Detail:
Created Date:  2008-10-28     Completed Date:  2009-01-21     Revised Date:  2014-09-11    
Medline Journal Info:
Nlm Unique ID:  1302422     Medline TA:  Clin Chim Acta     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  21-6     Citation Subset:  IM    
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MeSH Terms
Aged, 80 and over
Biological Markers
Cartilage Oligomeric Matrix Protein
Circadian Rhythm
Collagen Type II / genetics,  metabolism
Eating / physiology*
Extracellular Matrix Proteins / genetics,  metabolism
Glycoproteins / genetics,  metabolism
Hyaluronic Acid / genetics,  metabolism
Keratan Sulfate / genetics,  metabolism
Knee / radiography
Matrilin Proteins
Middle Aged
Motor Activity / physiology*
Osteoarthritis / diagnosis,  metabolism*,  radiography
Transforming Growth Factor beta / genetics,  metabolism
Grant Support
M01 RR000030/RR/NCRR NIH HHS; M01 RR000030-440760/RR/NCRR NIH HHS; M01-RR-30/RR/NCRR NIH HHS; P01 AR050245/AR/NIAMS NIH HHS; P01 AR050245-019001/AR/NIAMS NIH HHS; P01 AR50245/AR/NIAMS NIH HHS; R01 AR048769/AR/NIAMS NIH HHS; R01 AR048769/AR/NIAMS NIH HHS; R01 AR048769-05/AR/NIAMS NIH HHS
Reg. No./Substance:
0/Biological Markers; 0/Cartilage Oligomeric Matrix Protein; 0/Collagen Type II; 0/Epitopes; 0/Extracellular Matrix Proteins; 0/Glycoproteins; 0/Matrilin Proteins; 0/TSP5 protein, human; 0/Transforming Growth Factor beta; 9004-61-9/Hyaluronic Acid; 9056-36-4/Keratan Sulfate

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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