| Variation in hemostatic parameters after intra-arterial and intravenous administration of iodinated contrast media. | |
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MedLine Citation:
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PMID: 1473919 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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RATIONALE AND OBJECTIVES: A few case reports have suggested a possible thrombogenic effect of nonionic contrast media. In vitro investigations have lead to conflicting results. The authors performed three ex vivo studies to evaluate the influence of an ionic, ioxaglate, and a nonionic, iopamidol, low-osmolality contrast medium on a series of clotting and fibrinolytic parameters, after intravenous or intra-arterial administration, during routine diagnostic procedures. METHODS: In the first study, iopamidol was given to 20 consecutive patients through an arterial catheter for digital subtraction arteriography (DSA). In the second study, iopamidol was compared with ioxaglate. The media were randomly and blindly administered intravenously to 21 consecutive patients undergoing brain computed tomography (CT). Finally, ioxaglate was administered intra-arterially to 20 consecutive patients, in a situation comparable with that of the first study. RESULTS: In the first study, a weak anticoagulant effect and an activation of fibrinolysis were found, associated with indirect markers of thrombin generation, such as increased plasma levels of fibrinopeptide A (FpA) and thrombin-antithrombin III complexes (TAT). In the second study, no significant changes were seen with either contrast medium, for thrombin or fibrinolysis activation parameters. In the third study, the intra-arterially administered contrast medium elicited a marked increase of FpA and TAT, together with an anticoagulant effect. CONCLUSION: Both ionic and nonionic contrast media are able to interfere with the clotting/fibrinolytic system in the general circulation when they are administered to patients at the usual dosages. Ioxaglate shows more marked anticoagulant and thrombin-generating effects than iopamidol. The procedure (ie, arterial catheter versus intravenous infusion) seems to be more important than the category of contrast medium in conditioning the magnitude of these effects. |
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Authors:
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C Manotti; R Quintavalla; U Ugolotti; C Del Favero; A G Dettori |
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Publication Detail:
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Type: Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial |
Journal Detail:
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Title: Investigative radiology Volume: 27 ISSN: 0020-9996 ISO Abbreviation: Invest Radiol Publication Date: 1992 Dec |
Date Detail:
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Created Date: 1993-01-29 Completed Date: 1993-01-29 Revised Date: 2010-03-24 |
Medline Journal Info:
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Nlm Unique ID: 0045377 Medline TA: Invest Radiol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 1025-30 Citation Subset: IM |
Affiliation:
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Centro Malattie Emostatiche, Ospedale Regionale di Parma, Italy. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Angiography, Digital Subtraction Antithrombin III / analysis Blood Coagulation Tests Brain / radiography Fibrinogen / analysis Fibrinopeptide A / analysis Hemostasis / drug effects* Humans Injections, Intra-Arterial Injections, Intravenous Iopamidol / administration & dosage*, diagnostic use, pharmacology Ioxaglic Acid / administration & dosage*, diagnostic use, pharmacology Leg / blood supply Peptide Hydrolases / analysis Plasminogen Activator Inhibitor 1 / blood Tissue Plasminogen Activator / blood Tomography, X-Ray Computed |
| Chemical | |
Reg. No./Substance:
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0/Plasminogen Activator Inhibitor 1; 0/antithrombin III-protease complex; 25422-31-5/Fibrinopeptide A; 59017-64-0/Ioxaglic Acid; 62883-00-5/Iopamidol; 9000-94-6/Antithrombin III; 9001-32-5/Fibrinogen; EC 3.4.-/Peptide Hydrolases; EC 3.4.21.68/Tissue Plasminogen Activator |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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