| Variation in the gene encoding the serotonin transporter is associated with a measure of sociopathy in alcoholics. | |
| | |
MedLine Citation:
|
PMID: 20192950 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
The present study examined the association between a measure of sociopathy and 5-HTTLPR genotype in a sample of individuals from Project MATCH, a multi-center alcohol treatment trial. 5-HTTLPR, an insertion-deletion polymorphism in SLC6A4, the gene encoding the serotonin transporter protein, results in functionally distinct long (L) and short (S) alleles. The S allele has been associated with a variety of psychiatric disorders and symptoms including alcohol dependence, but it is unknown whether 5-HTTLPR increases the risk for co-morbid sociopathy among those with alcohol dependence. Eight hundred sixty-two subjects diagnosed with alcohol dependence completed the California Psychological Inventory, a psychological assessment that includes a measure of socialization, which was used as a proxy measure of sociopathy. Subjects were genotyped for the insertion-deletion polymorphism, as well as a single nucleotide polymorphism (A→G) that is located in the inserted region. Regression analysis revealed that after controlling for age, which was negatively related to socialization score, 5-HTTLPR genotype interacted with sex to determine socialization score (P < 0.001). Males with the L'L' genotype (i.e. those homozygous for the L(A) allele) had lower socialization scores (i.e. greater sociopathy) than males who were carriers of the S' allele (P = 0.03). In contrast, women with the S'S' genotype had lower socialization scores than women with two L' alleles (P = 0.002) and tended to have lower Socialization Index of the California Psychological Inventory scores than women with one copy of the L' allele (P = 0.07). Among individuals with alcohol use disorders, the tri-allelic 5-HTTLPR polymorphism had opposite effects on socialization scores in men than women. The basis for this finding is unknown, but it may have implications for sub-typing alcoholics. |
| | |
Authors:
|
Aryeh I Herman; Tamlin S Conner; Raymond F Anton; Joel Gelernter; Henry R Kranzler; Jonathan Covault |
Publication Detail:
|
Type: Journal Article; Multicenter Study; Randomized Controlled Trial; Research Support, N.I.H., Extramural |
Journal Detail:
|
Title: Addiction biology Volume: 16 ISSN: 1369-1600 ISO Abbreviation: Addict Biol Publication Date: 2011 Jan |
Date Detail:
|
Created Date: 2010-11-30 Completed Date: 2011-04-25 Revised Date: 2012-01-04 |
Medline Journal Info:
|
Nlm Unique ID: 9604935 Medline TA: Addict Biol Country: United States |
Other Details:
|
Languages: eng Pagination: 124-32 Citation Subset: IM |
Copyright Information:
|
© 2010 The Authors. Journal compilation © 2010 Society for the Study of Addiction. |
Affiliation:
|
Department of Psychiatry, University of Connecticut Health Center, Farmington, CT 06030-2103, USA. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adult Alcoholics Anonymous Alcoholism / genetics*, rehabilitation Alleles* Antisocial Personality Disorder / genetics*, rehabilitation Cognitive Therapy Female Gene Frequency / genetics Genetic Variation / genetics* Genotype Humans Male Middle Aged Motivation Personality Inventory Polymorphism, Genetic / genetics* Psychotherapy Serotonin Plasma Membrane Transport Proteins / genetics* Sex Factors |
| Grant Support | |
ID/Acronym/Agency:
|
K24 AA13736/AA/NIAAA NIH HHS; M01 RR06192/RR/NCRR NIH HHS; P50 AA03510/AA/NIAAA NIH HHS; R01 AA015606/AA/NIAAA NIH HHS; R01 AA015606-04/AA/NIAAA NIH HHS; R01 AA11330/AA/NIAAA NIH HHS |
| Chemical | |
Reg. No./Substance:
|
0/SLC6A4 protein, human; 0/Serotonin Plasma Membrane Transport Proteins |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: CNR1 gene polymorphisms in addictive disorders: a systematic review and a meta-analysis.
Next Document: Increased effects of 3,4-methylenedioxymethamphetamine (ecstasy) in a rat model of depression.