| Variation in fat, lactose and protein in human milk over 24 h and throughout the first year of lactation. | |
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MedLine Citation:
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PMID: 12117425 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Fat in human milk is extremely variable and can represent up to 50 % of infant energy intake. To accurately determine milk composition and infant intake at 1 (n 17), 2 (n 17), 4 (n 17), 6 (n 15), 9 (n 6) and 12 (n 5) months of lactation, samples of fore- and hind-milk were collected from each breast at each feed over 24 h periods from an initial group of seventeen women. The content of fat in milk varied over 24 h, with a mean CV of 47.6 (se 2.1) % (n 76) and 46.7 (se 1.7) % (n 76) for left and right breasts respectively. The 24 h amounts of fat, lactose and protein in milk differed between women (P=0.0001), but were consistent between left and right breasts. Daily milk production differed between breasts (P=0.0001) and women (P=0.0001). Accordingly, amounts of fat (P=0.0008), lactose (P=0.0385) and protein (P=0.0173) delivered to the infant over 24 h also differed between breasts and women (P=0.0001). The energy content of milk and the amount of energy delivered to the infant over 24 h were the same between breasts, but differed between women (P=0.0001). The growth rate of a group of only six infants in the present study was not related to either the concentrations or amounts of fat, lactose, protein and energy in milk over the first 6 months of life. These results show the individuality of milk composition and suggest that only a rigorous sampling routine that takes into account all levels of variation will allow the accurate determination of infant intake of fat, lactose, protein and energy. |
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Authors:
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Leon R Mitoulas; Jacqueline C Kent; David B Cox; Robyn A Owens; Jillian L Sherriff; Peter E Hartmann |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: The British journal of nutrition Volume: 88 ISSN: 0007-1145 ISO Abbreviation: Br. J. Nutr. Publication Date: 2002 Jul |
Date Detail:
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Created Date: 2002-07-15 Completed Date: 2002-08-01 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 0372547 Medline TA: Br J Nutr Country: England |
Other Details:
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Languages: eng Pagination: 29-37 Citation Subset: IM |
Affiliation:
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Department of Biochemistry, The University of Western Australia, 35 Stirling Highway, Crawley, Australia. Leon.Mitoulas@uwa.edu.au |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Child Development / physiology Female Follow-Up Studies Growth / physiology Humans Infant Infant Nutritional Physiological Phenomena / physiology Infant, Newborn Lactation / physiology* Lactose / analysis, metabolism* Lipid Metabolism* Lipids / analysis Milk Proteins / analysis, metabolism* Milk, Human / chemistry, metabolism* |
| Chemical | |
Reg. No./Substance:
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0/Lipids; 0/Milk Proteins; 63-42-3/Lactose |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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