Document Detail

Variation in fat, lactose and protein in human milk over 24 h and throughout the first year of lactation.
MedLine Citation:
PMID:  12117425     Owner:  NLM     Status:  MEDLINE    
Fat in human milk is extremely variable and can represent up to 50 % of infant energy intake. To accurately determine milk composition and infant intake at 1 (n 17), 2 (n 17), 4 (n 17), 6 (n 15), 9 (n 6) and 12 (n 5) months of lactation, samples of fore- and hind-milk were collected from each breast at each feed over 24 h periods from an initial group of seventeen women. The content of fat in milk varied over 24 h, with a mean CV of 47.6 (se 2.1) % (n 76) and 46.7 (se 1.7) % (n 76) for left and right breasts respectively. The 24 h amounts of fat, lactose and protein in milk differed between women (P=0.0001), but were consistent between left and right breasts. Daily milk production differed between breasts (P=0.0001) and women (P=0.0001). Accordingly, amounts of fat (P=0.0008), lactose (P=0.0385) and protein (P=0.0173) delivered to the infant over 24 h also differed between breasts and women (P=0.0001). The energy content of milk and the amount of energy delivered to the infant over 24 h were the same between breasts, but differed between women (P=0.0001). The growth rate of a group of only six infants in the present study was not related to either the concentrations or amounts of fat, lactose, protein and energy in milk over the first 6 months of life. These results show the individuality of milk composition and suggest that only a rigorous sampling routine that takes into account all levels of variation will allow the accurate determination of infant intake of fat, lactose, protein and energy.
Leon R Mitoulas; Jacqueline C Kent; David B Cox; Robyn A Owens; Jillian L Sherriff; Peter E Hartmann
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The British journal of nutrition     Volume:  88     ISSN:  0007-1145     ISO Abbreviation:  Br. J. Nutr.     Publication Date:  2002 Jul 
Date Detail:
Created Date:  2002-07-15     Completed Date:  2002-08-01     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0372547     Medline TA:  Br J Nutr     Country:  England    
Other Details:
Languages:  eng     Pagination:  29-37     Citation Subset:  IM    
Department of Biochemistry, The University of Western Australia, 35 Stirling Highway, Crawley, Australia.
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MeSH Terms
Child Development / physiology
Follow-Up Studies
Growth / physiology
Infant Nutritional Physiological Phenomena / physiology
Infant, Newborn
Lactation / physiology*
Lactose / analysis,  metabolism*
Lipid Metabolism*
Lipids / analysis
Milk Proteins / analysis,  metabolism*
Milk, Human / chemistry,  metabolism*
Reg. No./Substance:
0/Lipids; 0/Milk Proteins; 63-42-3/Lactose

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