Document Detail


Variation in blood pressure is associated with white matter microstructure but not cognition in African Americans.
MedLine Citation:
PMID:  20230114     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Although hypertension is a major risk factor for cerebrovascular disease (CVD) and is highly prevalent in African Americans, little is known about how blood pressure (BP) affects brain-behavior relationships in this population. In predominantly Caucasian populations, high BP is associated with alterations in frontal-subcortical white matter and in executive functioning aspects of cognition. We investigated associations among BP, brain structure, and neuropsychological functioning in 52 middle-older-age African Americans without diagnosed history of CVD. All participants underwent diffusion tensor imaging for examination of white matter integrity, indexed by fractional anisotropy (FA). Three regions of interest were derived in the anterior (genu) and posterior (splenium) corpus callosum and across the whole brain. A brief neuropsychological battery was administered from which composite scores of executive function and memory were derived. Blood pressure was characterized by mean arterial blood pressure (MABP). When controlling for age, higher MABP was associated with lower FA in the genu, and there was a trend for this same relationship with regard to whole-brain FA. When the sample was broken into groups on the basis of treatment for BP regulation (medicated vs. nonmedicated), MABP was related to genu and whole-brain FA only in the nonmedicated group. Neither MABP nor FA was significantly related to either neuropsychological composite score regardless of medication use. These data provide important evidence that variation in BP may contribute to significant alterations in specific neural regions of white matter in nonmedicated individuals without symptoms of overt CVD.
Authors:
Elizabeth C Leritz; David H Salat; William P Milberg; Victoria J Williams; Caroline E Chapman; Laura J Grande; James L Rudolph; David M Schnyer; Colleen E Barber; Lewis A Lipsitz; Regina E McGlinchey
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural    
Journal Detail:
Title:  Neuropsychology     Volume:  24     ISSN:  1931-1559     ISO Abbreviation:  Neuropsychology     Publication Date:  2010 Mar 
Date Detail:
Created Date:  2010-03-16     Completed Date:  2010-06-15     Revised Date:  2013-08-23    
Medline Journal Info:
Nlm Unique ID:  8904467     Medline TA:  Neuropsychology     Country:  United States    
Other Details:
Languages:  eng     Pagination:  199-208     Citation Subset:  IM    
Copyright Information:
Copyright 2010 APA, all rights reserved
Affiliation:
VA Boston Healthcare System and Brigham, & Women's Hospital. bleritz@nmr.mgh.harvard.edu
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MeSH Terms
Descriptor/Qualifier:
African Americans
Age Factors
Aged
Aged, 80 and over
Analysis of Variance
Anisotropy
Blood Pressure / physiology*
Brain / anatomy & histology,  physiology*
Cerebrovascular Disorders / diagnosis,  drug therapy,  etiology*,  pathology
Cognition / physiology*
Diffusion Magnetic Resonance Imaging / methods
Female
Humans
Male
Middle Aged
Nerve Fibers, Myelinated
Neuropsychological Tests
Risk Assessment / methods
Statistics as Topic
Grant Support
ID/Acronym/Agency:
F32NS051942/NS/NINDS NIH HHS; K01AG24898/AG/NIA NIH HHS; K23 NS062148-01/NS/NINDS NIH HHS; K23 NS062148-05/NS/NINDS NIH HHS; K23NS062148/NS/NINDS NIH HHS; P01AG004390/AG/NIA NIH HHS; P60AG08812/AG/NIA NIH HHS; R01 NR010827/NR/NINR NIH HHS; R01NR010827/NR/NINR NIH HHS; R03 AG029861-02/AG/NIA NIH HHS
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