Document Detail

Variation in the vitamin D receptor gene is not associated with risk of colorectal cancer in the Czech Republic.
MedLine Citation:
PMID:  20585998     Owner:  NLM     Status:  MEDLINE    
PURPOSE: Increased levels of vitamin D may protect against colorectal cancer (CRC) development and recurrence. Accumulating epidemiologic evidence suggests these effects may be partly mediated by genetic variants of the vitamin D receptor (VDR) proposed to be associated with altered risk of CRC. We wished to determine if common VDR polymorphisms affected CRC risk in the Czech Republic, a homogenous European population with a high CRC incidence rate.
METHODS: Frequencies of the common VDR gene polymorphisms rs2238136, rs1544410 (BsmI), rs7975232 (ApaI), and rs731236 (TaqI) were determined using allele-specific PCR in a case control analysis of a series of 754 CRC patients and 627 patients without malignant disease recruited from centers throughout the Czech Republic. Unconditional logistic regression was used to calculate odds ratios and 95% confidence intervals for the association between these variants and risk of CRC.
RESULTS: None of the four polymorphisms tested had any significant effect on CRC risk. No significant differences were observed in susceptibility when the population was stratified by anatomical sub-site, sex, BMI, smoking, alcohol, or presence of polyps.
CONCLUSIONS: We conclude that common variation in the VDR gene had little effect on its own on predisposition to sporadic CRC in the Czech population.
David J Hughes; Ivona Hlavatá; Pavel Soucek; Barbara Pardini; Alessio Naccarati; Ludmila Vodickova; Mazda Jenab; Pavel Vodicka
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of gastrointestinal cancer     Volume:  42     ISSN:  1941-6636     ISO Abbreviation:  J Gastrointest Cancer     Publication Date:  2011 Sep 
Date Detail:
Created Date:  2011-08-01     Completed Date:  2011-12-06     Revised Date:  2012-09-07    
Medline Journal Info:
Nlm Unique ID:  101479627     Medline TA:  J Gastrointest Cancer     Country:  United States    
Other Details:
Languages:  eng     Pagination:  149-54     Citation Subset:  IM    
Department of Clinical Medicine, Trinity College Centre for Health Sciences, Adelaide and Meath Hospital, Dublin 24, Ireland.
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MeSH Terms
Aged, 80 and over
Case-Control Studies
Colon / metabolism
Colorectal Neoplasms / genetics*
Czech Republic
DNA / genetics
Middle Aged
Polymerase Chain Reaction
Polymorphism, Genetic / genetics*
Receptors, Calcitriol / genetics*
Rectum / metabolism
Risk Factors
Vitamin D / metabolism
Reg. No./Substance:
0/Receptors, Calcitriol; 1406-16-2/Vitamin D; 9007-49-2/DNA

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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