| Variation in the vitamin D receptor gene is not associated with risk of colorectal cancer in the Czech Republic. | |
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MedLine Citation:
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PMID: 20585998 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PURPOSE: Increased levels of vitamin D may protect against colorectal cancer (CRC) development and recurrence. Accumulating epidemiologic evidence suggests these effects may be partly mediated by genetic variants of the vitamin D receptor (VDR) proposed to be associated with altered risk of CRC. We wished to determine if common VDR polymorphisms affected CRC risk in the Czech Republic, a homogenous European population with a high CRC incidence rate. METHODS: Frequencies of the common VDR gene polymorphisms rs2238136, rs1544410 (BsmI), rs7975232 (ApaI), and rs731236 (TaqI) were determined using allele-specific PCR in a case control analysis of a series of 754 CRC patients and 627 patients without malignant disease recruited from centers throughout the Czech Republic. Unconditional logistic regression was used to calculate odds ratios and 95% confidence intervals for the association between these variants and risk of CRC. RESULTS: None of the four polymorphisms tested had any significant effect on CRC risk. No significant differences were observed in susceptibility when the population was stratified by anatomical sub-site, sex, BMI, smoking, alcohol, or presence of polyps. CONCLUSIONS: We conclude that common variation in the VDR gene had little effect on its own on predisposition to sporadic CRC in the Czech population. |
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Authors:
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David J Hughes; Ivona Hlavatá; Pavel Soucek; Barbara Pardini; Alessio Naccarati; Ludmila Vodickova; Mazda Jenab; Pavel Vodicka |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of gastrointestinal cancer Volume: 42 ISSN: 1941-6636 ISO Abbreviation: J Gastrointest Cancer Publication Date: 2011 Sep |
Date Detail:
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Created Date: 2011-08-01 Completed Date: 2011-12-06 Revised Date: 2012-09-07 |
Medline Journal Info:
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Nlm Unique ID: 101479627 Medline TA: J Gastrointest Cancer Country: United States |
Other Details:
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Languages: eng Pagination: 149-54 Citation Subset: IM |
Affiliation:
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Department of Clinical Medicine, Trinity College Centre for Health Sciences, Adelaide and Meath Hospital, Dublin 24, Ireland. hughesd4@tcd.ie |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Aged, 80 and over Case-Control Studies Colon / metabolism Colorectal Neoplasms / genetics* Czech Republic DNA / genetics Female Humans Male Middle Aged Polymerase Chain Reaction Polymorphism, Genetic / genetics* Prognosis Receptors, Calcitriol / genetics* Rectum / metabolism Risk Factors Vitamin D / metabolism |
| Chemical | |
Reg. No./Substance:
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0/Receptors, Calcitriol; 1406-16-2/Vitamin D; 9007-49-2/DNA |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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